T hrombosis of a coronary or cerebral artery is the most common cause of mortality and morbidity in the developed nations.' The proximate cause is most often atherosclerosis, and the most appropriate intervention is its prevention. Much progress has been made in identifying the risk factors predisposing to atherosclerosis, and, perhaps because of their recognition, a significant decrease in the...

In this study, we examined the effects of various plasminogen activators on arachidonic acid release and prostacyclin biosynthesis in cultured rat aortic smooth muscle cells and bovine pulmonary artery endothelial cells. Prostacyclin was the major product formed from arachidonic acid in aortic smooth muscle cells and endothelial cells. When intact cells were incubated with streptokinase, one of...

The existence of significant synergism between tissue-type plasminogen activator (t-PA) and single-chain urokinase-type plasminogen activator (scu-PA), and between t-PA and urokinase in thrombolysis in vivo is described. In a quantitative preparation of thrombolysis, consisting of rabbits in which a blood clot was induced in the jugular vein with 125I-labeled fibrin, intravenous infusion over 4...

In this study, the role of the staphylococcal plasminogen activator, staphylokinase (SAK), was analyzed for its ability to mediate acquisition of cell-associated plasmin-like activity by staphylococci in the presence of a source of human plasminogen. A panel of staphylococcal strains isolated from humans was tested for the presence of the SAK gene, secretion of the plasminogen activator, and th...

We determined the distribution of genotypes and frequencies of alleles of the (CA)(n) repeat polymorphism in intron 3 of the urokinase plasminogen activator receptor (uPAR) gene, uPAR antigen levels and microvessel density (MVD) in tumour and distant mucosa samples from 52 patients with colorectal cancer. The uPAR level was higher for patients with high MVD comparing to patients with lower MVD ...

interaction between urokinase-type plasminogen activator (upa) and its receptor (upar) plays an important role in the progression of numerous cancer types including breast cancer by promoting tumor initiating,  proliferation,  invasion  and  metastasis.  hence,  disruption  of  this  interaction  inhibits  their downstream cascades and subsequently tumor growth. for this, we created two series ...