نتایج جستجو برای: urokinase

تعداد نتایج: 6601  

Journal: :Tumori 2008
Kyung Hee Lee Eun Young Choi Myung Soo Hyun Jong Ryul Eun Byung Ik Jang Tae Nyeun Kim Heon Ju Lee Dong Shik Lee Sung Su Yun Hong Jin Kim Jung Hye Kim Jae-Ryong Kim

AIMS AND BACKGROUND The hepatocyte growth factor, its receptor c-Met, and urokinase-type plasminogen mediate various cellular responses on activation, including proliferation, survival, invasion, and metastasis. The regulatory mechanisms for the proliferation and the particular invasive phenotypes of hepatocellular carcinoma are not yet fully understood. In order to clarify the intracellular do...

1991
Sae Yong Hong Dong Ho Yang Byoung Ho Lee Eun Kyong Ki Kwang Hoe Chung

To see whether there was any difference in the urine urokinase concentration between acquired cystic kidney disease (ACKD) group and control (non cyst) group in end stage renal disease patients (ESRD), we evaluated fifty ESRD patients who had been maintained on chronic hemodialysis for various period. The urine urokinase concentration was higher in the ACKD group (17.5 +/- 14.7 unit/ml, range 1...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2003
Stephen M Carlin Michael Roth Judith L Black

We investigated the chemotactic action of PDGF and urokinase on human airway smooth muscle (HASM) cells in culture. Cells were put in collagen-coated transwells with 8-micro m perforations, incubated for 4 h with test compounds, then fixed, stained, and counted as migrated nuclei by microscopy. Cells from all culture conditions showed some basal migration (migration in the absence of stimuli du...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2001
R T Schermuly A Günther M Ermert L Ermert H A Ghofrani N Weissmann F Grimminger W Seeger D Walmrath

Alveolar fibrin generation has been suggested to possess strong surfactant-inhibitory potency. In perfused rabbit lungs, fibrin formation in the alveolar space was induced by sequential ultrasonic aerosolization of fibrinogen and thrombin, and the efficacy of rescue administration of surfactant and urokinase was investigated. Ventilation-perfusion (VA/Q) distribution was assessed by the multipl...

Journal: :Cancer research 1989
D Boyd B Ziober S Chakrabarty M Brattain

Conditioned medium derived from the colon cancer cell lines was ineffective in solubilizing immobilized radiolabeled laminin. However, substantial degradation was observed in the presence of plasminogen and could be largely blocked by preincubation with polyclonal anti-urokinase antibody. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the solubilized products generated either by t...

Journal: :Cancer research 1996
C Simon J Juarez G L Nicolson D Boyd

The elevated expression of the urokinase-type plasminogen activator gene, which is necessary for the invasive phenotype of several types of cancers, is controlled by growth factors such as epidermal growth factor, transforming growth factor a, and fibroblast growth factor which bind to and activate protein tyrosine kinase transmembrane receptors. Since these activated receptors communicate with...

Journal: :The Journal of clinical investigation 1982
C Korninger O Matsuo R Suy J M Stassen D Collen

Extrinsic (tissue-type) plasminogen activator (plasminogen activator) was isolated either as a single-chain or as a two-chain molecule from the culture medium of a human melanoma cell line. The thrombolytic activity of both molecular forms of activator was investigated in beagle dogs with an experimental femoral vein thrombosis and compared with that of urokinase. The 125I-fibrinogen-labeled th...

2016
Yanping Zhu Lina Guan Yuming Mu

This paper aims to study the thrombolytic effect of low-frequency ultrasound combined with targeted urokinase-containing microbubble contrast agents on treatment of thrombosis in rabbit femoral artery; and to determine the optimal combination of parameters for achieving thrombolysis in this model. A biotinylated-avidin method was used to prepare microbubble contrast agents carrying urokinase an...

2005
M. A. Solomatina O. S. Plekhanova M. Yu. Men’shikova E. I. Ratner V. A. Tkachuk E. V. Parfenova

Russian Research and Production Center of Cardiology, Moscow. Ad dress for correspondence: [email protected]. E. V. Parfenova Remodeling of the vascular wall is a critical stage in the pathogenesis of vascular diseases, including arterial hypertension, atherosclerosis, and restenosis after balloon angioplasty [2,6,11,12]. Urokinase plasminogen activator (urokinase) plays a key role in arteria...

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