inTrodUcTion Radical cystectomy for bladder and urinary diversion is considered the gold standard for treatment of muscular invasive bladder cancer or high‐risk nonmuscular invasive bladder cancer. Urinary diversion is usually classified into three types: orthotopic neobladder, ileal conduit or sigmoid conduit, and cutaneous ureterostomy.[1] Orthotopic neobladder is a better choice for urinary ...

Exosomes are nanometer-sized vesicles, secreted by various cell types, present in biological fluids that are particularly rich in membrane proteins. Ex vivo analysis of exosomes may provide biomarker discovery platforms and form non-invasive tools for disease diagnosis and monitoring. These vesicles have never before been studied in the context of bladder cancer, a major malignancy of the urolo...

BACKGROUND Colorectal, endometrial and upper urinary tract tumours are characteristic for Lynch syndrome (hereditary non-polyposis colon carcinoma, HNPCC). The aim of the present study was to establish whether carriers of mutations in mismatch repair genes MLH1, MSH2 or MSH6 are at increased risk of urinary bladder cancer. METHODS Carriers and first degree relatives of 95 families with a germ...

Objective: To evaluate programmed death-ligand 1 immunohistochemical expression in the available variants of urinary bladder carcinoma, and to correlate its with clinicopathological features.Method: The retrospective study was conducted at Faculty Medicine, Kafrelsheikh University, Egypt, from February 2020 April 2021, comprised formalin-fixed paraffin-embedded specimens carcinoma belonging pat...

Compromised activity of the DNA repair enzymes may raise the risk of a number of cancers. We analyzed polymorphisms in the Xeroderma Pigmentosum, Complementation Group C (XPC) gene for their correlation with urinary bladder cancer. Ala499Val and Lys939Gln polymorphisms were genotyped in 234 urinary bladder cancer cases and 258 control samples. A significant association between Ala499Val polymor...

Received June 2008 Accepted August 2008 INTRODUCTION Pelvic irradiation is known to cause several complications involving urinary bladder such as radiation cystitis, ulceration, and incontinence.(1,2) Spontaneous intraperitoneal rupture of the urinary bladder is a rare complication following pelvic irradiation.(3-5) To the best of our knowledge, there is only one report of radiation-induced bla...

PURPOSE The aim of this study was to identify noninvasive pharmacodynamic biomarkers of FGFR3-targeted therapies in bladder cancer to facilitate the clinical development of experimental agent targeting FGFR3. EXPERIMENTAL DESIGN Potential soluble pharmacodynamic biomarkers of FGFR3 were identified using a combination of transcriptional profiling and biochemical analyses in preclinical models....

BACKGROUND Prostate cancer is the sixth most common cancer worldwide and will include about 30% of all malignancies in men. Since the initial report of the anatomic radical prostatectomy, refinements in the surgical technique have been made. Several studies show that bladder neck preservation (BNP) during radical prostatectomy makes improve early return of urinary continence, erectile function ...

Urothelial carcinomas are malignant tumours originating from the epithelial layer of urinary bladder. In this instance, a case papillary and infiltrative urothelial carcinoma in bladder 2-year-old terrier dog was defined clinically, histopathologically immunohistochemically. The material presented consisted tissue samples that were surgically extirpated two-year-old terrier-breed female applied...

Bladder cancer is a common malignancy of the urinary tract, which generally develops in the epithelial lining of the urinary bladder. The specific course of treatment depends on the stage of bladder cancer; however, therapeutic strategies typically involve intravesical drug delivery to reduce toxicity and increase therapeutic effects. Recently, metallic, polymeric, lipid, and protein nanopartic...