BACKGROUND In recent years, the PLCE1 rs2274223 polymorphism has been extensively investigated as a potential risk factor for upper gastrointestinal cancers, including squamous cell carcinoma (ESCC) and gastric cancer. However, the results of these studies have been inconsistent. METHODS A meta-analysis of 13 case-control studies was performed including more than 11,000 subjects with genotype...

abstractbackground: pathogenicity ofthe helicobacter pylori-caga positive was associated with epiyamotifs and higher number of epiya-c segments is a risk for gastric cancer,while duodenal ulcer-promoting gene (dupa) is determinedas a protective factor against gastric cancer. our aim was to determine the epiya-cagaphosphorylation sites and dupa gene in h. pylori isolates amongpatients with upper...

BACKGROUND Wnt signalling dysregulation has been implicated in cancer, including colon and gastric cancer. Initiation of Wnt signalling is modulated by soluble Wnt antagonists (sWAs), including soluble frizzled related proteins, dickkopf (Dkk) proteins, and Wnt inhibitory factor-1 (Wif1). AIMS To evaluate the role of sWAs in upper (gastric) and lower (colon) gastrointestinal tract tumorigenes...

Background: Gastrointestinal cancers are among the most common cancers in different communities. Gastrointestinal tract cancer is the most common cancer among Iranian men and the second common cancer among Iranian women. Due to the impact of environmental factors on the risk of gastrointestinal cancer and the increasing use of agricultural pesticides, this study aimed to investigate the effects...

The authors discuss the potential influence of obesity surgery on the risk of cancer, focusing on the upper GI tract directly affected by operations. There is currently no substantiation for an increased risk of cancer after bariatric surgery, because there are only about 25 reports of subsequent cancer of the esophagus and the stomach. However, this review emphasizes the need to detect potenti...

background: this study aimed to compare intermittent intravenous (iv) pantoprazole and ranitidine for control of gastric acid secretion and the possible prevention of upper gastrointestinal bleeding (ugib) in critical care patients. methods: this was a randomized, double blind clinical trial study of iv pantoprazole (40 mg every12 hour) or intermittent iv ranitidine (50 mg bolus every 8 hour) i...