Oral bioavailability of a drug compound is the significant property for potential drug candidates. Measuring this property can be costly and time-consuming. Quantitative structure-property relationships (QSPRs) are used to estimate the percentage of oral bioavailability, and they are an attractive alternative to experimental measurements. A data set of 217 drug and drug-like compounds with meas...

This paper describes Transis, a communication sub-system for high availability. Transis is a transport layer package that supports a variety of reliable multicast message passing services between processors. It provides highly tuned multicast and control services for scalable systems with arbitrary topology. The communication domain comprises of a set of processors that can initiate multicast m...

BACKGROUND Patient flow from intensive care to acute care units is often problematic and many discharges from intensive care to acute care are unsuccessful on the first attempt. OBJECTIVES The aim of this study was to explore the factors that influence intensive care patient discharge. DESIGN, SETTING, AND PARTICIPANTS This ethnographic study was undertaken in an Australian metropolitan ter...

OBJECTIVE To determine the impact of transferring a pediatric population to mechanical ventilator dependency units (MVDUs) or to home mechanical ventilation (HMV) on bed availability in the pediatric intensive care unit (ICU). METHODS This is a longitudinal, retrospective study of hospitalized children who required prolonged mechanical ventilation at the MVDU located at the Hospital Auxiliar ...

When examining the CPU utilization of midrange servers in an enterprise, at first glance, they often appear to be significantly under-utilized. Is that really the case? This paper discusses how high availability, load balancing, multiple standards (platforms, operating systems, middleware services, etc.), and application incompatibility affect the amount of computing capability which is actuall...

dissolution and oral bioavailability of different formulations of two essential drugs marketed in Tanzania, the drug content and drug release from all the tested ciprofloxacin formulations were within USP-24 requirements and remained stable during storage at simulated tropical conditions. Oral bioavailability was also not influenced by tropical conditions. The stability of essential drugs (ampi...

Beverages stored in lead-crystal glass accumulate extraordinary concentrations of lead. We obtained a lead-crystal decanter manufactured with lead from Australia, where the ratio of 206Pb/207Pb is distinctly different from that in the United States. We sought to determine the bioavailability of crystal-derived lead, using the technique of stable isotope dilution in blood. We conducted a single-...

PK express module is a physiologically based model of first pass metabolism, which integrates in vitro data with an in silico physiologically based pharmacokinetic (PBPK) model to predict human bioavailability (F(H)). There are three required inputs: FDp (Fraction dose absorbed, final parameter from iDEA absorption module), protein binding (fu) and disappearance kinetics in human hepatocytes. C...

Deep Neural Networks are becoming increasingly popular in always-on IoT edge devices performing data analytics right at the source, reducing latency as well as energy consumption for data communication. This paper presents CMSIS-NN, efficient kernels developed to maximize the performance and minimize the memory footprint of neural network (NN) applications on Arm Cortex-M processors targeted fo...

Background : One of the indices of health care development is the use of HIS, but it is not supporting the nursing process as a scientific method. So, this study was done in order to optimize Hospital Information System (HIS) in cardiac care unit with the approach of “nursing care using scientific method”. Materials and Methods: This study is a part of a participatory action research which w...