Nail psoriasis is considered a significant psychological and social problem causing functional impairment in affected patients. Nail changes hamper their daily and occupational activities and contribute to a worse quality of life. Almost 50% of patients with psoriasis vulgaris and up to 80% of patients with psoriatic arthritis are afflicted with nail lesions. The important correlation between p...

BACKGROUND Melasma is a common chronic and relapsing acquired dyschromia. Skin microneedling was reported resulting sustained long-term improvement of recalcitrant melasma, however, the exact mechanism that promotes this skin lightening is not known. This study aimed to investigate clinical and histologic alterations promoted by skin microneedling in facial melasma. METHODS Open pilot trial i...

BACKGROUND Cutaneous amyloidosis has been classified into primary cutaneous amyloidosis (PCA, OMIM #105250), secondary cutaneous amyloidosis and systemic cutaneous amyloidosis. PCA is the deposition of amyloid in previously apparent normal skin without systemic involvement. Amyloidosis cutis dyschromica (ACD) is a rare distinct type of PCA. Here, the unique clinical and histological findings of...

Background: The interest in maintaining a young and attractive appearance an era with increasingly hectic rhythms has generated pressing demand for effective aesthetic procedures the shortest possible recovery period, stimulating search non-invasive, yet successful, solutions. aim of this study was to evaluate effectiveness combined soft peeling MN technique on various imperfections typical fac...

Background & Aim: Recent studies have demonstrated visible light and long-wavelength UVA1 (VL+UVA1, 370-700 nm) to cause erythema in skin synergistically increased pigmentation dark subjects.1, 2 Spectral compositions of VL+UVA1 may further impact these biologic effects. Yet, no phototesting guidelines exist, thus hindering the development reliable sunscreens protective against this part sunlig...

The aim of this study was an assessment of the overall optical characteristics changes in volume of the dentin, after the diffusion of the chemical components included in the sealer throughout the endodontic space, in order to demonstrate the discoloration effect of the endodontic sealer on tooth crown of a recently extracted maxillary premolar. Thin sections were studied using the polarized tr...

Microneedling (MN) is a novel therapeutic modality in dermatology. Through physical trauma from needle penetration, MN induces a wound healing cascade with minimal damage to the epidermis. This allows for enhancement in the absorption of mainstay topical therapies across the thick stratum corneum. MN has become increasingly utilized over the last several years as it is a relatively simple proce...