In general, the therapy of differentiated thyroid carcinoma (DTC), includes initial treatment and follow-up of patients. Nowadays, there is no universal accepted consensus regarding initial treatment of DTC patients. Several countries have their own guidelines and recommendations for treatment of DTC . Beside all controversies, mostly accepted recommendation regarding initial treatment of DTC i...

Thyroglobulin is a large protein present in all vertebrates. It is synthesized in the thyrocytes and exported to lumen of the thyroid follicle, where its tyrosine residues are iodinated . The iodinated thyroglobulin is reintegrated into the cell and processed (cleaved to free its two extremities) for thyroid hormone synthesis. Thyroglobulin sequence analysis has identified four regions of the m...

AIMS Strong thyroglobulin immunoreactivity within sinus histiocytes in a lymph node draining a papillary thyroid carcinoma was observed in a recent case. This prompted the investigation of whether thyroglobulin immunoreactivity is common in regional lymph nodes in cases of thyroid malignancy. METHODS Eighty seven lymph nodes were studied from 21 cases of thyroid malignancy. These comprised pa...

We have used DNase I footprinting to examine the interaction of several triplex-binding ligands with antiparallel TG- and AG-containing triplexes. We find that although a 17mer TG-containing oligonucleotide on its own fails to produce a footprint at concentrations as high as 30 microM, this interaction can be stabilised by several ligands. Within a series of disubstituted amidoanthraquinones we...

Signature-based detection provides a relatively simple and efficient method for detecting known viruses. At present, most antivirus systems rely primarily on signature

Immunohistochemical studies were conducted in 20 cases of canine thyroid tumours. On histological grounds the tumours included four well-differentiated follicular and four well-differentiated medullary carcinomas. Four tumours were suspected to be of possible follicular origin but were poorly-differentiated or anaplastic (undifferentiated); similarly six tumours that were poorly-differentiated ...

In response to the re-emergence of iodine deficiency in New Zealand, in 2009 the government mandated that all commercially made breads be fortified with iodized salt. There has been no evaluation of the impact of the program on iodine status of the elderly, despite this population group being vulnerable to iodine deficiency or excess. The aim of this study was to describe the iodine status of e...

Differentiated thyroid cells expressing polyoma Middle-T became transformed and tumorigenic when injected into syngenic animals. The expression of thyroglobulin was greatly reduced and no longer responsive to thyrotropin (TSH) and to cAMP. Inhibition of endogenous c-ras by the expression of two transdominant negative mutant H-ras genes, Asn17 and Leu61-Ser186, reactivated thyroglobulin synthesi...