نتایج جستجو برای: ultrasound microbubble

تعداد نتایج: 109355  

2010
Zhi-Yi Chen Kun Liang Ri-Xiang Qiu

BACKGROUND Noninvasive and tissue-specific technologies of gene transfection would be valuable in clinical gene therapy. This present study was designed to determine whether it could enhance gene transfection in vivo by the combination of ultrasound-targeted microbubble destruction (UTMD) with polyethylenimine (PEI) in tumor xenografts, and illuminate the effects of gene silencing and apoptosis...

Journal: :Arthritis and rheumatism 2005
Hiroyuki Nakaya Tominaga Shimizu Ken-ichi Isobe Keiji Tensho Takahiro Okabe Yukio Nakamura Masashi Nawata Hideki Yoshikawa Kunio Takaoka Shigeyuki Wakitani

OBJECTIVE To evaluate whether microbubble-enhanced ultrasound (US) treatment promotes the delivery of methotrexate (MTX) into synovial cells and the enhanced antiinflammatory effects of intraarticular MTX therapy in a rabbit arthritis model. METHODS Arthritis was induced in both knees of 53 rabbits by immunization with ovalbumin. MTX including a microbubble agent was then injected into the le...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2006
Joshua J Rychak Jonathan R Lindner Klaus Ley Alexander L Klibanov

Ultrasound contrast microbubbles have been successfully targeted to a number of intravascular disease markers. We hypothesized that targeted delivery could be improved further, by making the microbubbles deformable, leading to increased microbubble-endothelium adhesion contact area and stabilized adhesion. Activated leukocytes utilize such strategy; they deform after binding to inflamed endothe...

Journal: :JNMA; journal of the Nepal Medical Association 2008
K Maruyama M Yoshikawa O Yokosuka

Hepatocellular carcinoma has a decisive influence on the prognosis of cirrhotic patients, and the use of imaging modalities is essential for the screening, diagnosis and treatment of hepatocellular carcinoma. Ultrasound plays a major role among them, because it provides real-time and non-invasive observation by a simple and easy technique. In addition, ultrasound-guided needle puncture methods ...

2012
Steven C Wood Sible Antony Ronald P Brown Jin Chen Edward A Gordon Victoria M Hitchins Qin Zhang Yunbo Liu Subha Maruvada Gerald R Harris

BACKGROUND Ultrasound (US) imaging can be enhanced using gas-filled microbubble contrast agents. Strong echo signals are induced at the tissue-gas interface following microbubble collapse. Applications include assessment of ventricular function and virtual histology. AIM While ultrasound and US contrast agents are widely used, their impact on the physiological response of vascular tissue to v...

Journal: :Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2002
James F Zachary Sarah A Hartleben Leon A Frizzell William D O'Brien

OBJECTIVE To develop an animal model suitable for characterizing electrocardiographic arrhythmias in hearts exposed to ultrasound after injection of a microbubble contrast agent. METHODS Conduction complex and heart lesion data were recorded from 20 rats that received intravenous injections of 0.25 mL of a contrast agent and were exposed to pulsed ultrasound (frequency, 3.1 MHz; pulse duratio...

2015
James Shue-Min Yeh Charles A. Sennoga Ellen McConnell Robert Eckersley Meng-Xing Tang Sussan Nourshargh John M. Seddon Dorian O. Haskard Petros Nihoyannopoulos Christoph E Hagemeyer

RATIONALE Microbubbles conjugated with targeting ligands are used as contrast agents for ultrasound molecular imaging. However, they often contain immunogenic (strept)avidin, which impedes application in humans. Although targeting bubbles not employing the biotin-(strept)avidin conjugation chemistry have been explored, only a few reached the stage of ultrasound imaging in vivo, none were report...

2015
Yan Xu Zongyuan Xie Yu Zhou Xiyuan Zhou Pan Li Zhigang Wang Qunxia Zhang

PURPOSE The purpose of this study was to investigate whether ultrasound-targeted cationic microbubble destruction could effectively deliver endostatin-green fluorescent protein (ES-GFP) plasmids to human retinal vascular endothelial cells (HRECs). METHODS Cationic microbubbles (CMBs) were prepared and then compared with neutral microbubbles (NMBs) and liposomes. First, the two types of microb...

Journal: :Current pharmaceutical biotechnology 2013
Wang Tzu-Yin Katheryne E Wilson Steven Machtaler Jurgen K Willmann

Ultrasound mediated drug delivery using microbubbles is a safe and noninvasive approach for spatially localized drug administration. This approach can create temporary and reversible openings on cellular membranes and vessel walls (a process called "sonoporation"), allowing for enhanced transport of therapeutic agents across these natural barriers. It is generally believed that the sonoporation...

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