Acid peptic diseases are common gastrointestinal disorders, which include gastroesophageal reflux disease, peptic ulcers, non-ulcer dyspepsia and stressrelated gastric mucosal injury. Drugs commonly used in the management of these disorders include antacids, H2 blockers, proton pump inhibitors and mucosal protective agents. In this chapter, pharmacology of these drugs will be discussed, followe...

rrhe marked resistance of the glandular stomach of animals to spontaneously occurring cancer is well known. A similar resistance to the experi mental production of cancer has been observed, since carcinogenic agents have been fed to mice and rats without producing cancer of the glandular stomach (6) . However, when threads saturated with methylcholanthrene were imbedded in the mucosa of the sto...

BACKGROUND Several studies have suggested that proton pump inhibitors are efficacious in preventing rebleeding when administered immediately after endoscopic treatments. However, there are limited clinical outcome data on the use of intravenous pantoprazole. OBJECTIVE To evaluate the efficacy of intravenous pantoprazole after successful endoscopic treatment for peptic ulcer bleeding using evi...

Current anti-gastric ulcer agents have side effects, despite the progression and expansion of advances in treatment. This study aimed to investigate the gastroprotective mechanisms of Pithecellobium jiringa ethanol extract against ethanol-induced gastric mucosal ulcers in rats. For this purpose, Sprague Dawley rats were randomly divided into five groups: Group 1 (normal control) rats were orall...

The rapidly declining prevalence of Helicobacter pylori infection and widespread use of potent anti-secretory drugs means peptic ulcer disease has become substantially less prevalent than it was two decades ago. Management has, however, become more challenging than ever because of the threat of increasing antimicrobial resistance worldwide and widespread use of complex anti-thrombotic therapy i...

Post-transplant lymphoproliferative disorder (PTLD) is associated with a variety of clinical presentations, but rarely involves the skin. We herein report a case of PTLD presenting with skin ulceration in a renal transplant recipient. A biopsy of the ulcer confirmed the diagnosis of diffuse large B-cell lymphoma. The patient was initially treated with immunosuppression reduction, but the skin u...

on " Oriental Sore" by Captain Henry Smith, I.M.S. In the course of this article under the heading of "Treatment" he condemns " nitric acid and such agents" as "unnecessarily severe," because " they remove the sound with the diseased tissues and leave a scar larger than is necessary, a point of importance when the ulcer happens to be on the face." The treatment, however, which he recommends, na...

Corresponding Author: Kenji Sasaki, Home Medical Care Supporting Clinic Sendai, 30-3, Kabanomachi, Wakabayashi Ward, Sendai, Miyagi, 984-0037, Japan, Tel: +81-80-1817-8414; E-mail: [email protected] Abstract Candida-associated gastric ulcer, though formerly thought to affect only debilitated persons, has been reported to occur in apparently healthy individuals. Though had been reporte...

Digestive diseases are the sixth leading cause of death in world and accounted for more than 2.5 million deaths 2019. In Ukraine, mortality from digestive system is recorded as one highest world, place general structure occupied by peptic ulcer disease (РUD).
 The aim study. Summarize current information on etiology pathogenesis РUD characterize modern approaches to treatment patients with...

Acid peptic diseases are common gastrointestinal disorders, which include gastroesophageal reflux disease, peptic ulcers, non-ulcer dyspepsia and stressrelated gastric mucosal injury. Drugs commonly used in the management of these disorders include antacids, H2 blockers, proton pump inhibitors and mucosal protective agents. In this chapter, pharmacology of these drugs will be discussed, followe...