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OBJECTIVE To review the currently available information on the pharmacology, pharmacokinetics, efficacy, adverse effects, drug interactions, and dosage guidelines of voriconazole. Comparative data for voriconazole and other azole antifungal agents are described where available. DATA SOURCES A MEDLINE search restricted to English-language articles (1966 to September 1999) was conducted, and an...
L-dopa is a potentiator for presynaptic beta-adrenoceptors. We studied whether L-dopa potentiates the activities of other presynaptic receptors to modulate the evoked noradrenaline (NA) release in rat hypothalamic slices. UK14304 (0.1-1 microM), a selective alpha 2-agonist, concentration-dependently inhibited NA release. Noneffective 10 pM L-dopa potentiated the UK14304-induced inhibition. This...
Antiplatelet drugs as exemplified by aspirin are used frequently to prevent stroke. Aspirin inhibits the formation of both the potent platelet aggregator, thromboxane A2 and the potent anti-aggregator, prostacyclin. Another approach to the inhibition of platelet aggregation might involve selective suppression of thromboxane formation. We report our experience in swine with UK-38,485, a drug whi...
Sildenafil [SIL (Viagra); Pfizer, New York, NY] is a widely prescribed agent for erectile dysfunction in men older than 65 years. The present study evaluated experimental models to assess age-dependent changes in SIL biotransformation using hepatic microsomes from male rats and mice ranging from 6 weeks to 26 months of age. The role of specific isoforms in the conversion of SIL to its primary c...
UK-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin A structurally related to amikacin. It was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. The spectrum and degree of activity of UK-18892 were similar to those of amikacin, and differences were relatively minor. UK-18892 was about twice as active as amikacin again...
In this paper, a packet-loss resilient, bandwidth-scalable 3-D graphics streaming system is proposed. It uses the Compressed Progressive Mesh (CPM) algorithm [1] to generate a hierarchical bit-stream to represent different levels of details (LODs). We assign forward error correction (FEC) codes to each layer in the encoded bit-stream according to its importance. To this end, we develop a new di...
Mobile TVs have been available for many years, without ever becoming very popular. Moreover, the first wave of research has been mostly concerned with technology and standards, which are necessary to ensure interoperability and market acceptance. Although, there has been a significant body of computer supported co-operative work (CSCW) and mobile human-computer interaction (HCI) research findin...
c Additional data are given in the three Appendices published online only at http://thorax.bmj. com/content/vol63/issue3 1 Centre for Workplace Health, Sheffield, UK; 2 Centre for Workplace Health, Buxton, UK; 3 University of Aberdeen, Aberdeen, UK; 4 Heartlands Hospital, Birmingham, UK; 5 Queen’s Medical Centre, Nottingham, UK; 6 Royal Brompton Hospital, London, UK; 7 G P Research Unit, North ...
Perry MBChB, University of Cambridge, UK; KK Ray MD, University of Cambridge, UK; N Sarwar PhD, University of Cambridge, UK; M Alexander MPhil, University of Cambridge, UK; A Thompson PhD, University of Cambridge, UK; SG Thompson DSc, MRC Biostatistics Unit, UK; M Walker PhD, University of Cambridge, UK; S Watson MMath, University of Cambridge, UK; F Wensley MSc, University of Cambridge, UK; IR...
Programme Committee A. Al-Dubai, Napier University, UK Hamid R. Arabnia, Univ. of Georgia, USA Frank Ball, Bournemouth University, UK Luciano Bononi, University of Bologna, Italy Azzedine Boukerche, University of Ottawa, Canada Jeremy Bradley, Imperial College London, UK Songqing Chen, George Mason University, USA Karim Djemame, University of Leeds, UK Jose Gil, Motorola, UK Wei Guo, Nokia Rese...
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