Images for social media are an essential component of any blog or post. As we now live in the age 'camera everyone's pocket', a new dynamic era image creation and content has emerged. However, people use due to specific motives gratifications that lead their satisfaction use. This research study utilized uses gratification theory (UGT), sociology related using media. The UGT factors include enj...

The UDP-glucuronosyltransferases (UGTs) are enzymes of the phase II metabolic system. These enzymes catalyze the transfer of α-D-glucuronic acid from UDP-glucuronic acid to aglycones bearing nucleophilic groups affording exclusively their corresponding β-Dglucuronides to render lipophilic endobiotics and xenobiotics more water soluble. This detoxification pathway aids in the urinary and biliary...

UDP-glucuronosyltransferases (UGTs), located in the endoplasmic reticulum of liver cells, are an important family enzymes, responsible for biotransformation several endogenous and exogenous chemicals, including therapeutic drugs. However, phenomenon 'latency', i.e., full UGT activity revealed by disruption microsomal membrane, poses substantial challenges predicting drug clearance based on vitr...

The stereoand regioselective glucuronidation of 10 -3-keto monohydroxylated androgens and pregnanes was investigated to identify UDP-glucuronosyltransferase (UGT) enzyme-selective substrates. Kinetic studies were performed using human liver microsomes (HLMs) and a panel of 12 recombinant human UGTs as the enzyme sources. Five of the steroids, which were hydroxylated in the 6 -, 7 -, 11 or 17 -p...

Lorcaserin, a selective serotonin 5-HT(2C) receptor agonist, is a weight management agent in clinical development. Lorcaserin N-carbamoyl glucuronidation governs the predominant excretory pathway of lorcaserin in humans. Human UDP-glucuronosyltransferases (UGTs) responsible for lorcaserin N-carbamoyl glucuronidation are identified herein. Lorcaserin N-carbamoyl glucuronide formation was charact...

Phase II metabolism is prominently governed by UDP-glucuronosyltransferases (UGTs) in humans. These enzymes regulate the bioactivity of many drugs and endogenous small molecules in many organs, including the liver, a major site of regulation by the glucuronidation pathway. This study determined the expression of hepatic UGTs by targeted proteomics in 48 liver samples and by measuring the glucur...