The production of reactive oxygen species (ROS) in mitochondria is very sensitive to the proton motive force and may be decreased by mild uncoupling, mediated e.g. by mitochondrial uncoupling proteins (UCPs). UCPs were conversely hypothesized to be activated by ROS. Conclusions from experiments studying the reactive product of lipid peroxidation 4-hydroxy-2-nonenal (HNE) in isolated mitochondri...

The uncoupling protein (UCP) of brown adipose tissue is a regulated proton carrier which allows uncoupling of mitochondrial respiration from ATP synthesis and, therefore, dissipation of metabolic energy as heat. In this article we demonstrate that, when UCP is expressed in Saccharomyces cerevisiae, it retains all its functional properties: proton and chloride transport, high-affinity binding of...

Academic publication metadata can be used to analyze the collaboration, productivity and hot topic trends of a research community. Recently, it is shown that authors with uninterrupted and continuous presence (UCP) over a time window, though small in number (about 1%), amass the majority of significant and high-influence academic output. We adopt the UCP metric to retrieve the most active autho...

We present a plan representation and a generalized algorithm template, called UCP, for unifying the classical plan-space and state-space planning approaches within a single framework. UCP models planning as a process of refining a partial plan. The plan-space and state-space planning approaches are cast as complementary refinement strategies operating on the same partial plan representation. UC...

The uncoupling protein 4 (ucp-4) gene is involved in age-dependent neurodegeneration in C. elegans. Therefore, we aimed to investigate the mechanism underlying the association between mitochondrial uncoupling and neurodegeneration by examining the effects of uncoupling agents and ucp-4 overexpression in C. elegans. Treatment with either DNP or CCCP improved neuronal defects in wild type during ...

The role of brown adipose tissue in total energy balance and cold-induced thermogenesis was studied. Mice expressing mitochondrial uncoupling protein 1 (UCP-1) from the fat-specific aP2 gene promoter (heterozygous and homozygous aP2-Ucp transgenic mice) and their nontransgenic C57BL6/J littermates were used. The transgenic animals are resistant to obesity induced by a high-fat diet, presumably ...

BACKGROUND Recurrent chest pain is common in patients with and without coronary artery disease. The prevalence and burden of these symptoms on healthcare is unknown. OBJECTIVES To compare chest pain return visits (recidivism) in patients with unexplained chest pain (UCP) against reference group of patients with coronary artery disease (CAD) and estimate the annual cost of recurrent chest pain...

Context: Predicting software project effort from Use Case Points (UCP) method is increasingly used among researchers and practitioners. However, unlike other estimation domains, this area of interest has not been systematically reviewed. Aims: There a need for systemic literature review to provide directions supports research estimation. Specifically, the objective study twofold: 1) classify UC...

The research work is an extension of the original UCP Model for software estimation by incorporating the factors that are currently weighted in estimation of software by IT professionals. The rationale of the study is to make UCP Model effective, realistic and more accurate for the current IT industry. To identify the gap between the original UCP model and the current estimation considerations,...