We studied the regulation of the individual natriuretic peptide receptor subtypes by 12-O-tetradecanoylphorbol 13-acetate (TPA) and forskolin in cultured bovine aortic endothelial and smooth muscle cells. In cultured endothelial cells, 10(-8) mol/L TPA caused a reduction in atrial natriuretic peptide (ANP) receptor binding activity that was seen as early as 2 hours after the treatment and reach...

Running title: Vascular interactions between ANP and NO Classification: Biological Sciences, Physiology Manuscript information: 21 pages, 6 figures; abstract with 245 words, 5151 words in total. Abbreviations footnote: ANP, atrial natriuretic peptide; CNP, C-type natriuretic peptide; NO, nitric oxide; GC-A, guanylyl cyclase-A; sGC, soluble guanylyl cyclase; PKG I, cGMPdependent Protein Kinase I...

3. Borges FK, Furtado MV, Rossini AP, Bertoluci C, Gonzalez VL, Bertoldi EG, et al. Prognostic value of perioperative N-terminal pro-B-type natriuretic peptide in noncardiac surgery. Arq Bras Cardiol. 2013;100(6):561-70. 4. Scotti AV, Tura BR, Rocha RG, Albuquerque DC. Prognostic value of B-type natriuretic peptide in the mortality of patients with acute coronary syndrome. Arq Bras Cardiol. 201...

Methods Fifty-four patients four months after acute STEMI were enrolled in this cross-sectional, single-center study. Nterminal pro B-type natriuretic peptide (NT-proBNP), mid-regional pro-A-type natriuretic peptide (MR-proANP) and mid-regional pro-adrenomedullin (MR-proADM) levels were measured by established assays. Aortic stiffness was assessed by the measurement of pulse wave velocity using...

Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are similar in their ability to promote natriuresis and diuresis and act as vasodilators. These actions are counterbalanced by the vasoconstrictive and sodium-retaining actions of the renin-angiotensinaldosteron system. Both systems help to maintain sodium and fluid volume homeostasis in a healthy cardio-renal environment. C-t...

We tested both relaxation and cGMP generation by atrial (ANP), brain (BNP), and C-type natriuretic peptide (CNP) in oxytocin-stimulated myometrium from near-term pregnant guinea pigs to investigate the ability and mechanism of natriuretic peptides to inhibit myometrial contractility. Myometrial strips were contracted by 10(-8) M oxytocin, and relaxation to the cumulative addition (10(-9)-10(-6)...

Activation of the natriuretic peptide system lowers blood pressure and causes the excretion of salt. Atrial natriuretic peptide and B-type natriuretic peptide are the humoral mediators of this effect; they act primarily by binding to membrane-bound natriuretic peptide receptor A (NPRA) and stimulating its intrinsic guanylate cyclase activity. To study whether genetically determined differences ...

This study tested the hypothesis that atrial natriuretic peptide has direct antihypertrophic actions on the heart by modulating expression of genes involved in cardiac hypertrophy and extracellular matrix production. Hearts of male, atrial natriuretic peptide-null and control wild-type mice that had been subjected to pressure overload after transverse aortic constriction and control unoperated ...

UNLABELLED INTRODUCTION Little is known about the responses of natriuretic peptides to developing congestive heart failure in 'anephric' end-stage kidney disease. CASE PRESENTATION We present three consecutive cases of surgically-induced anephric patients in a critical care environment: a 28-year-old Caucasian woman (with congestive heart failure), a 42-year-old Caucasian woman (without co...