AIM We studied the correlations between fasting and post-lunch serum IGF-I concentrations, and insulin resistance and insulin sensitivity in subjects with various degrees of glucose tolerance. MATERIALS AND METHODS A total of 12 nondiabetic subjects, 09 subjects with impaired glucose tolerance (IGT) and 18 patients with newly diagnosed type-2 diabetes of either sex (mean age, 46 years) were r...

The majority of diabetic patients who are overweight or obese die of heart disease. We suspect that the obesity-induced insulin resistance may lead to abnormal cardiac electrophysiology. We tested this hypothesis by studying an obese insulin-resistant rat model, the obese Zucker rat (OZR). Compared with the age-matched control, lean Zucker rat (LZR), OZR of 16-17 wk old exhibited an increase in...

The aim of this study was to assess the implications of insulin resistance on the clinical and biochemical profiles of Korean type 2 diabetic patients. 122 patients with type 2 diabetes underwent a short insulin tolerance test to assess insulin resistance. Subjects were classified in tertiles according to ISI (insulin sensitivity index), and the tertile I (the insulin- resistant group) and tert...

OBJECTIVE To determine whether first-degree relatives of individuals with type 2 diabetes, who are at high risk of subsequently developing hyperglycemia, manifest alterations in beta-cell function including an alteration in the co-release of insulin and amylin. RESEARCH DESIGN AND METHODS In 30 first-degree relatives and 24 matched subjects with no family history of diabetes, beta-cell functi...

Diabetes mellitus is responsible for billions in annual healthcare costs, is a leading cause of premature death inthe US, and is a driving factor of end-stage renal disease, heart disease, blindness, and amputations in the industrialized world. Managing diabetes is complex and can have significant impacts on quality of life. Traditional insulin pumps, whether subdermal, transdermal, or wearable...

OBJECTIVE To investigate the hypoglycaemic effects of repeated sublingual doses of human insulin for the treatment of hyperglycaemia in type I diabetes. DESIGN Clinical trial. SETTING A Private clinic. METHOD Eight insulin dependent diabetic males with a mean age of 27 years (range 18-32 years) presenting with hyperglycaemia were given 1 U/Kg body weight of human soluble insulin in 5 equa...

Diabetes mellitus is a metabolic disease characterized by hyperglycaemia resulting from either defect in insulin secretion, insulin action, or both. Though, there exists many therapeutics for the treatment of diabetes, plant based drugs are generally considered safe and are much effective. However, traditional usage of medicinal plants for the treatment of diabetes lacks scientific validation. ...

The aim of this study was to design a controlled release vehicle for insulin to preserve its stability and biological activity during fabrication and release. A modified, double emulsion, solvent evaporation, technique using homogenisation force optimised entrapment efficiency of insulin into biodegradable nanoparticles (NP) prepared from poly (DL-lactic-co-glycolic acid) (PLGA) and its PEGylat...