Angiogenesis is a critical step in the growth and dissemination of malignant diseases, including pancreatic cancer. Twist has been shown to stimulate angiogenesis in the tumor site. However, whether Twist contributes to angiogenesis in pancreatic cancer remains unknown. In this paper, we found that the expression of Twist was significantly increased in human pancreatic cancer cell lines and pan...

Twist-three analysis of photon electroproduction off pion. Abstract We study twist-three effects in spin, charge, and azimuthal asymmetries in deeply virtual Compton scattering on a spin-zero target. Contributions which are power suppressed in 1/Q generate a new azimuthal angle dependence of the cross section which is not present in the leading twist results. On the other hand the leading twist...

Twist is a key transcription activator of epithelial-mesenchymal transition (EMT). It remains unclear how Twist induces gene expression. Here we report a mechanism by which Twist recruits BRD4 to direct WNT5A expression in basal-like breast cancer (BLBC). Twist contains a "histone H4-mimic" GK-X-GK motif that is diacetylated by Tip60. The diacetylated Twist binds the second bromodomain of BRD4,...

Twist is required in Drosophila embryogenesis for mesodermal specification and cell-fate choice. We have examined the role of Twist and Notch during adult indirect flight muscle development. Reduction in levels of Twist leads to abnormal myogenesis. Notch reduction causes a similar mutant phenotype and reduces Twist levels. Conversely, persistent expression, in myoblasts, of activated Notch cau...

BACKGROUND Long-term peritoneal dialysis (PD) results in functional and structural alterations of the peritoneal membrane. Previous studies have suggested that high glucose (HG) could induce transdifferentiation of peritoneal mesothelial cells into myofibroblasts, but the molecular mechanisms of HG-induced epithelial-to-mesenchymal transition (EMT) of human peritoneal mesothelial cells (HPMCs) ...

cold roll-forming is a process in which the roll of sheet is formed by passing continuously through the set of rotary rollers without changing thickness in a cool way until it is formed to the desired profile. in this paper a parametric study on the section twist angle in roll-forming the non-symmetric channel is presented, using finite element simulation. at first finite element simulation res...

AIMS Speckle tracking has emerged as a quantitative technique for assessing left ventricular (LV) function. However, no normative data for LV twist using speckle tracking echocardiography (STE) are available in the black population. This study assessed myocardial mechanics by determining LV twist parameters in different age groups using STE, and evaluated the effect of ageing on LV twist in thi...

objectives our aim was to study the relation between vac and the parameters of myocardial mechanics using three-dimensional speckle-tracking echocardiography (3dste). patients and methods we studied 68 normal participants (mean age, 35 ± 12.2 y; 36 [53%] males). vac was measured by the ratio of arterial elastance (ea) to ventricular elastance (ees). the peak systolic value of longitudinal strai...

In this paper a method is presented for torsional analysis of non-homogeneous tubes with arbitrarily shaped cross-sections. A previously presented method based on Bredt’s theory is extended to achieve formulas for torsional analysis. Shear modulus varies through the thickness according to a power law distribution. To validate the accuracy of the presented formulas for angle of twist and shear s...

We study twist-three effects in spin, charge, and azimuthal asymmetries in deeply virtual Compton scattering on a spin-zero target. Contributions which are power suppressed in 1/Q generate a new azimuthal angle dependence of the cross section which is not present in the leading twist results. On the other hand the leading twist terms are not modified by the twist three contributions. They may g...