Metastasis, the cardinal feature of malignant tumors, is an important clinical variable in patient prognosis. To understand the basis for metastasis, we systematically selected for highly invasive cells from breast cancer cell lines, MCF7 and MDA-MB-453, with moderate to low invasive ability using Boyden chamber invasion assay. The four-cycle selected invasive lines, named MCF7-I4 and MDA-MB-45...

In palatogenesis, the MEE (Medial Edge Epithelium) cells disappear when palates fuse. We hypothesize that the MEE cells undergo EMT (Epithelial-Mesenchymal Transition) to achieve mesenchyme confluence. Twist has an important role in EMT for tumor metastasis. The purpose of this study was to analyze Twist function during palatal fusion. Twist protein was expressed in palatal shelves and MEE both...

In this research, optimization process of axisymmetric extrusion dies is proposed. Plastic zone is analyzed using finite element method in the Eulerian system with flow formulation. The die profiles are defined by Bezier curves with six control points. Two effective functions are considered in this research; standard deviation of the strain rate and the rate of energy consumption during extrusi...

We present and analyze the Esoteric Twist algorithm for the Lattice Boltzmann Method. Esoteric Twist is a thread safe in-place streaming method that combines streaming and collision and requires only a single data set. Compared to other in-place streaming techniques, Esoteric Twist minimizes the memory footprint and the memory traffic when indirect addressing is used. Esoteric Twist is particul...

In this paper we study the twist disclination within the elastoplastic defect theory. Using the stress function method, we found exact analytical solutions for all characteristic fields of a straight twist disclination in an infinitely extended linear isotropic medium. The elastic stress, elastic strain and displacement have no singularities at the disclination line. We found modified stress fu...

regarding the increasing demand for lightweight concrete especially lightweight structural concrete, and safety requirements underlined in 2800 iranian standard, research to achieve the optimized results in lightweight concrete production seems inevitable. since, one of the commonly used methods for producing the light eight concrete, utilizes the light weight aggregates with significant role i...

Members of the Twist-family of bHLH proteins play a pivotal role in a number of essential developmental programs. Twist-family bHLH proteins function by dimerizing with other bHLH members and binding to cis- regulatory elements, called E-boxes. While Twist-family members may simply exhibit a preference in terms of high-affinity binding partners, a complex, multilevel cascade of regulation creat...