Abstract Background Increasing evidence indicates that radiotherapy (RT) has synergistic inhibitory efficiency with immunotherapy agents in multiple cancers and enhances abscopal effects by regulating the innate immune response, which was further investigated this study. Neutrophils are recruited radiated tumors. Therefore, neutrophil membrane-coated nanoparticles potentially deliver R837 (Toll...

Near infrared fluorescence (NIRF) imaging has strong potential for widespread use in noninvasive tumor imaging. Indocyanine green (ICG) is the only Food and Drug Administration (FDA) -approved NIRF dye for clinical diagnosis; however, it is unstable and poorly targets tumors. DZ-1 is a novel heptamethine cyanine NIRF dye, suitable for imaging and tumor targeting. Here, we compared the fluoresce...

Tumor targeting with immunomodulatory molecules is an attractive strategy to enhance the host's antitumor response. Expression of CD80 (B7-1) and CD86 (B7-2) costimulatory molecules in tumor cells has proven to be an efficient way to enhance their immunogenicity. Here, we studied the effects of tumor targeting with biotinylated recombinant soluble B7-1- and B7-2 immunoglobulin G molecules (bio-...

Cancer Phototherapy The endoplasmic reticulum (ER) plays an important role in protein synthesis, processing and secretion. ER-targeting phototherapy significantly amplifies ER stress, promotes tumor antigen release, elicits a robust immunogenic cell death. In article number 2202728 by Weidong Wang, Junping Shenglin Luo, co-workers, small molecular heptamethine cyanine photosensitizer with binit...

Efficient treatment of disseminated ovarian cancer (OC) is challenging due to its heterogeneity and chemoresistance. Overexpression human epidermal growth factor receptor 2 (HER2) epithelial cell adhesion molecule (EpCAM) in approx. 30% 70% cancers, respectively, allows for co-targeted treatment. The clinical efficacy the monoclonal antibody trastuzumab patients with HER2-positive breast, gastr...

Docosahexaenoic acid (DHA), an omega-3 C22 natural fatty acid serving as a precursor for metabolic and biochemical pathways, was reported as a targeting ligand of anticancer drugs. However, its tumor targeting ability and mechanism has not been claimed. Here we hypothesized that the uptake of DHA by tumor cells is related to the phosphatidylethanolamine (PE) contents in cell membranes. Thus, in...

We report here a modified auxotrophic strain of Salmonella typhimurium that can target and cure breast tumors in orthotopic mouse models. We have previously reported development of a genetically modified strain of S. typhimurium, selected for prostate tumor targeting and therapy in vivo. The strain, termed S. typhimurium A1, selectively grew in prostate tumors in xenograft models causing tumor ...