BACKGROUND Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine which plays an important role in the immunopathogenesis of Behcet's disease (BD). B cell activating factor (BAFF) and its homolog A proliferation inducing ligand (APRIL) are members of the tumor necrosis factor family. BAFF binds to 3 receptors, B cell activating factor receptor (BAFF-R), transmembrane activ...

Objective: This study aimed to monitor oxidative stress parameters including total antioxidant status (TAS) and oxidant (TOS), tumor necrosis factor-alpha (TNF-α) level during the healing process in hair goats with metritis. 
 Materials Methods: was carried out on a of 25 metritis (n=10; Group 1) healthy (n=15; 2). The beginning accepted as day 0. In both 1 2, blood samples were collected ...

background the association between tumor necrosis factor-alpha (tnf-α) (-308 g/a) gene polymorphisms and level of tissue destruction and periodontal disease progression is not proved. objectives the present study investigated the stereological parameters of interdental papilla in chronic periodontitis (cp) patients with tnf-α (-308 g/a) gene polymorphisms. materials and methods sixty gingiva sa...

Codiaeum variegatum has been widely investigated for its biological proprieties ranging from the antiamoebic potential to phytochemical analysis. The aim of present study was evaluate anti-inflammatory C. leaf extracts and fractions. A primary macrophage culture activated by Saccharomyces cereviseae (SC) used cell cytotoxicity plant Macrophages were treated with different concentrations (0.1; 1...

Tumor necrosis factor-alpha (TNF-α) is a cytokine that plays an important role in inflammatory process and tumor development. Recent studies demonstrate that triterpene saponins from Vietnamese ginseng are efficient inhibitors of TNF-α. But the interactions between TNF-α and the saponins are still unclear. In this study, molecular docking and molecular dynamics simulations of TNF-α with three d...

the aim of this study was to investigate the immunomodulatory effects of spirulina platensis (s.platensis) by measuring the levels of serum interleukin (il)-4, il-10, il-17, tumor necrosis factor(tnf)-α and interferon (ifn)-|γ| in mice suffered from systemic candidiasis and breast cancer. theaqueous extract of s. platensis was selected for this study. balb/c female mice were inoculated withcand...

The aim of this study was to the impact Tumor Necrosis Factor-α (TNF-α) levels on dental caries demage in children with malignant tumors undergoing radiotherapy head and neck region. case-control included 48 aged between 1 18 years divided into 2 identical groups by structure. research group (Gr1) consisted 24 region at a distance 6 months - after completion (RT). conventionally healthy were co...

inflammatory bowel disease (ibd) is a chronic disease of unknown etiology, in which genetic factors, seem to play an important role in the disease predisposition and course. assessment of tumor necrosis factor (tnf-α) gene polymorphisms in many populations showed a possible association with ibd. considering the genetic variety in different ethnic groups, the aim of the present study was to inve...

tumor necrosis factor- α (tnf-α) plays an important role in diverse cellular events such as septic shock, induction of other cytokines, cell proliferation and apoptosis. tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is currently attracting great interest as a potential anticancer drug. trail could selectively induce apoptosis in tumor cells in vitro and in vivo by a deat...

The purpose of this study was to explore the effects of tumor necrosis factor-α (TNF-α) on ventricular fibrillation (VF) in rats with acute myocardial infarction (AMI). Rats were randomly classified into AMI group, sham operation group and recombinant human tumor necrosis factor receptor:Fc fusion protein (rhTNFR:Fc) group. Spontaneous and induced VFs were recorded. Monophasic action potentials...