Halophilic archaea are known as the novel producers of natural products and their supernatant metabolites could have cytotoxic effects on cancer cells. In the present study, we screened the anticancer potential of supernatant metabolites from eight native haloarchaeal strains obtained from a culture collection in Iran. Five human cancer cell lines including breast, lung, prostate and also human...

or quarterly cyclic hormone therapy (2 mg of estradiol on days 1-78 and 1 mg of estradiol on days 79-84, with 1 mg of norethindrone on days 69-78) was stopped after 2-3 years of the planned 5 years of treatment because of an unacceptably high rate of endometrial pathology (including one en-dometrial cancer) in the quarterly compared with the monthly cycle group (6.2% versus 0.8%; P ‫ס‬ .004). A...

Background: Nodular hidradenoma or clear cell hidradenoma is a rare adnexal tumor arising from the eccrine glands. Case Report: A 60-year old female presented to the surgical out-patient clinic with complaints of breast lump of one year duration. Fine needle aspirate (FNA) of the lump yielded fluidly asp...

Since secretory component is thought to be a normal glandular epithelial cell product, surgical specimens from patients with mammary carcinoma, an epithelial cancer, were studied with antisera to human free secretory compo nent by indirect immunofluorescence microscopy. Normal breast tissue (10 cases) showed fluorescent epithelial cells confined to normal ducts. This was in marked contrast to i...

the adhesive interaction between tumor cells and the host cells or the extracellular matrix plays a crucial role in tumor metastasis. to evaluate the mediation of cell adhesion by daphne mucronata, an anti-cancer medicinal plant in iranian folk medicine, the adhesion of thrombin activated human platelets to the cultured monocytes or hl-60 cells was investigated under the effect of the plant ext...

One of the important problems in microarray gene expression data is tumor classification. This paper proposes a new feature selection method for tumor classification using gene expression data. In this method, three dimensionality reduction methods, including principal component analysis (PCA), factor analysis (FA) and independent component analysis (ICA), are first introduced to extract and se...

Tumor outcomes (progression, response to immunotherapies) are influenced by tumor-intrinsic and the tumor-immune microenvironment (TiME) factors. To overcome existing limitations of phenotyping tumors using single-time, single-siteex vivo biopsies in predicting tumor behavior, we propose an integrated dynamic approach for TiME combining inflammation, vasculature/ angiogenesis features through h...

Halophilic archaea are known as the novel producers of natural products and their supernatant metabolites could have cytotoxic effects on cancer cells. In the present study, we screened the anticancer potential of supernatant metabolites from eight native haloarchaeal strains obtained from a culture collection in Iran. Five human cancer cell lines including breast, lung, prostate and also human...

BACKGROUND The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase, together constituting the tissue microenvironment. Here we focus on the interstitial fluid phase of tumors, i.e., the fluid bathing the tumor and stromal cells. Novel knowledge on this compartment may provide important insight into how tumors develop an...