IL-2 potentiates both growth and cytotoxic function of T lymphocytes and NK cells. Resting peripheral blood NK cells can respond directly to rIL-2, without requirement for accessory cells or cofactors, and enhanced cytotoxicity can be measured within a few hours after exposure to this lymphokine. In this study, we describe an activation antigen, Leu-23, that is rapidly induced and phosphorylate...

PURPOSE To analyze tumor-microenvironment relationships in Hodgkin lymphoma (HL) as potential determinants in the decision-making process related to the alterations in cell cycle and apoptotic pathways of Hodgkin/Reed-Sternberg (H/RS) cells. EXPERIMENTAL DESIGN Based on a cohort of 257 classic HL patients, we carried out a global descriptive correlational analysis and logistic regression stud...

Hematopoietic stem cell transplantation is the treatment of choice for many hematologic diseases, such as multiple myeloma, bone marrow aplasia and leukemia. Human leukocyte antigen (HLA) compatibility is an important tool to prevent post-transplant complications such as graft rejection and graft-versus-host disease, but the high rates of relapse limit the survival of transplant patients. Natur...

Abstract Background CD155 is an immune checkpoint protein that interacts with ligands on natural killer cells to regulate the tumor associated immunity. overexpression has been detected in many human cancer types. and its pathways are promising immunotherapy targets. We aimed evaluate immunohistochemical expression of invasive breast carcinomas correlate such pathological parameters tumors also...

Monoclonal antibodies targeting tumors are one of the most important discoveries in field cancer. Although several effective have been developed, a relapse may occur. One their mechanisms action is Antibody Dependent Cell Cytotoxicity (ADCC), by engaging Fc γ receptor CD16 expressing Natural Killer cells, innate lymphoid cells involved cancer immunosurveillance and able to kill tumor cells. A l...