Trichinellosis is one of the most important food-borne parasitic zoonoses throughout the world. Because infected pigs are the major source of human infections, and China is becoming the largest international producer of pork, the development of a transmission-blocking vaccine to prevent swine from being infected is urgently needed for trichinellosis control in China. Our previous studies have d...

BACKGROUND Modulation of the host immune response by helminths has been reported to be essential for parasite survival and also to benefit the host by suppressing inflammatory diseases such as allergies. We have previously shown that excretory-secretory products of Trichinella spiralis muscle larvae have immunomodulatory properties and induce in vitro the expansion of CD4(+) CD25(+) FOXP3(+) T...

BACKGROUND The recruitment of CD4+CD25+Foxp3+T (Treg) cells is one of the most important mechanisms by which parasites down-regulate the immune system. METHODOLOGY/PRINCIPAL FINDINGS We compared the effects of Treg cells from Trichinella spiralis-infected mice and uninfected mice on experimental allergic airway inflammation in order to understand the functions of parasite-induced Treg cells. ...

Trichinellosis is a foodborne zoonotic disease caused by Trichinella spp., including spiralis. In the present study, T. spiralis membrane-associated progesterone receptor component-2 (Ts-MAPRC2) gene was cloned and characterized using protein sequencing analysis. Furthermore, expression, purification, immunoblot assay, binding ability with antibody, immunofluorescence assay were performed. A di...

The influence of short chain fatty acids (SCFA) on histopathological changes in the small intestine and the intensity of invasion of T. spiralis in mice were investigated in this study. The animals were infected with doses of 500 and 250 T. spiralis larvae per mouse. A SCFA solution containing acetic, propionic and butyric acid (30 : 15 : 20mM) was administered orally to the mice starting from ...

BACKGROUND Our previous studies showed that Trichinella spiralis paramyosin (TsPmy) is an immunomodulatory protein that inhibits complement C1q and C8/C9 to evade host complement attack. Vaccination with recombinant TsPmy protein induced protective immunity against T. spiralis larval challenge. Due to the difficulty in producing TsPmy as a soluble recombinant protein, we prepared a DNA vaccine ...

(1993) Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): downregulation of specific cytokine secretion (IL-9 and IL-10) correlates with poor mastocytosis and chronic survival of adult worms. The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions...

Background: Trichinella spiralis causes trichinosis through ingestion of pork contaminated by its infectivelarvae, resulting in intestinal and muscular phases infection the same host. Stem cells (SCs) treatsome diseases due to their capacity for trans-differentiation immunomodulation.Objective: To assess therapeutic impact mesenchymal stem (MSCs) during andmuscular stages T. spiralis-experiment...

Trichinella spiralis infection is the major problem all over world. The trichinosis being human zoonotic disease has been subject of current research collected by many tours different localities. scheme identification based on “Systema helminthumˮ Vol III Yamaguti (1959).This study adds epidemiology and rediscovery in Aurangabad district.

The influence of anterior pituitary hormones on the gastrointestinal tract of humans and animals has been previously reported. Hypophysectomy (HYPOX) in the rat causes atrophy of the intestinal mucosa, and reduction of gastric secretion and intestinal absorption, as well as increased susceptibility to bacterial and viral infections. However, to our knowledge, no findings have been published con...