All the drugs used as analgesic agent have some systemic side effects. For the researchers, the prospects of overcoming the side effects of a drug, achieving an effect at a much lower dose is very attractive. Modification of the structure of a known drug is one way to develop new drugs. For this purpose, we have optimized the pyrimidobenzimidazole derivatives using molecular modeling studies. Q...

112 * I wish to thank the Gerda Henkel Stiftung, Germany, and Slavic Research Center at the University of Hokkaido, Japan, for financial support for the research and writing of this essay. For astute criticism and useful suggestions on its earlier draft, I am grateful to two anonymous readers of Acta Slavica Iaponica. The final version of the essay also benefited from discussions of my presenta...

Intrinsically disordered proteins (IDPs) have recently attracted much interest, due to their role in many biological processes, including signaling and regulation mechanisms. High-dimensional (13)C direct-detected NMR experiments have proven exceptionally useful in case of IDPs, providing spectra with superior peak dispersion. Here, two such novel experiments recorded with non-uniform sampling ...

Research objectives: To establish the degree of equivalence for status Nogai Horde in comparison with Tatar khanates that arose after collapse Golden Horde. materials: Russian-Nogai embassy books and documents about those living Russia 16th–17th centuries, writings pertaining to noble people from East. Results scientific novelty study: The Horde, until last third 16th century, retained institut...

Abstract This article explores the issue of Russian imperial nationalism in early phase its formation, namely nationalization patriotism literature during Crimean War, 1853–56. Using historical studies and theories nationalism, author shows how why an acute discourse a nationalistic experience community uniting elite with common people arose St. Petersburg society, theater, literature. Drawing ...

At the beginning of 17th century, Russia’s central government ordered peoples Siberia to swear oaths allegiance (shert’). The oath text determines that one who takes becomes a subject Russian monarch. appealed in case conflicts with or for avoiding such negotiations. Siberian had renew their whenever tsar changed (and nomadic leader as well). also called on when replacing governors towns, which...

The paper deals with three similar tales - Of too much Pride, the story about Emperor Jovinian from Gesta Romanorum (Oesterley, 1872), Story of Tsar Aggey and how he Suf?fered for Pride (Afanasev, Narodnye russkie legendy, 1859), Asa (Danicic, Three Old Tales, 1872). Asa, third king Kingdom Judah (2 Chronicles 14-16), is preserved in only one Serbian-Slavonic manuscript end 16th century (now Pa...

Toxicity evaluation is an extremely important process during drug development. It is usually initiated by experiments on animals, which is time-consuming and costly. To speed up such a process, a quantitative structure-activity relationship (QSAR) study was performed to develop a computational model for correlating the structures of 581 aromatic compounds with their aquatic toxicity to tetrahym...

Conventional wisdom and current research suggest that the Internet will lower electronic commerce (EC) product prices by causing intense competition among vendors. However, this does not seem to be happening. This research presents a multi-industry investigation of pricing behavior using a customized data-collecting Internet agent that we call the Time Series Agent Retriever (TSAR). We use theo...