BACKGROUND Previous small-sized studies showed lower thymidylate synthase (TS) expression in adenocarcinoma of the lung, which may explain higher antitumor activity of TS-inhibiting agents such as pemetrexed. PATIENTS AND METHODS To quantitatively measure TS gene expression in a large-scale Japanese population (n = 2621) with primary lung cancer, laser-captured microdissected sections were cu...

Translation studies (TS), as a young (inter)discipline, has partly relied on metadiscussions, critical assessments of its literature, and compilation of bibliographies to deal with certain problems of its youth, such as polarity and fragmentation. While the current status of TS shows general maturity, there are still young areas of inquiry in the discipline that are faced with similar issues. T...

Mouse FM3A mammary adenocarcinoma cells exposed to the specific thymidylate synthetase (TS) inhibitor 10-propargyl-5,8-dideazafolate (PDF) responded by overproducing TS up to 200-fold. In the absence of inhibitor, the elevation of TS levels decayed with a half-life of about 4 weeks. Southern blot analysis of restricted DNA from the PDF-resistant cells using a TS-specific probe showed that the T...

Examined children's ratings of attitudes and behavioral intentions toward a boy presented, on videotape, with or without symptoms of Tourette syndrome (TS). Effects of information about TS on these ratings were investigated as well as the influence of gender and grade. Children in Grades 3 and 5 were randomly assigned to one of three conditions: No TS, TS, or TS/information. On the attitude mea...

Temperature sensitivity of frog taste cells was studied. The taste cell designated Type thermosensitive (TS) I cell was depolarized by warm stimulus at 30 degrees C and hyperpolarized by cold stimulus at 10 degrees C. The taste cell designated Type TS II cell was depolarized by the cold stimulus and hyperpolarized by the warm stimulus. Menthol solution at 20 degrees C, which selectively activat...