BACKGROUND Endurance exercise can increase cardiac troponin (cTn) concentrations as high as those seen in cases of minor myocardial infarction. The inability of most cTn assays to reliably quantify cTn at very low concentrations complicates a thorough data analysis, and the clinical implications of such increases remain unclear. The application of recently developed highly sensitive cTn immunoa...

Featured Article: Bodor GS, Porter S, Landt Y, Ladenson JH. Development of monoclonal antibodies for an assay of cardiac troponin I and preliminary results in suspected cases of myocardial infarction. Clin Chem 1992;38:2203–14. In the early 1980s, David N. Dietzer and I started building a team to develop monoclonal antibodies to the isoenzymes then used for detecting cardiac damage: creatine ki...

It is now well known that, as compared to all other cardiac markers the cardiac Troponin-I and CK-MB are found to be more reliable for the diagnosis of myocardial infarction (MI). The aim of our study was to assess the comparative role of CK-MB and Troponin-I in the diagnosis of non-ST elevation MI (NSTEMI) where there is minimal cardiac damage. Design: The study comprised of 50 patients presen...

BACKGROUND Cardiac troponin testing is central to the diagnosis of acute myocardial infarction. We evaluated a sensitive troponin I assay for the early diagnosis and risk stratification of myocardial infarction. METHODS In a multicenter study, we determined levels of troponin I as assessed by a sensitive assay, troponin T, and traditional myocardial necrosis markers in 1818 consecutive patien...

BACKGROUND This study evaluates the association between high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) and coronary calcium concentration (CAC) detected by coronary computed tomography (CCT) and evaluated with the Agatston score in patients with suspected coronary artery disease (CAD). METHODS Patients undergoing CCT during routine clinical care were enrolled prospectively. CCT...

Cardiac troponins are specific biomarkers of cardiac injury. However, the prognostic usefulness of cardiac troponin in patients with acute ischemic stroke is still controversial. The objective of this meta-analysis was to investigate the association of cardiac troponin elevation with all-cause mortality in patients with acute ischemic stroke. PubMed and Embase databases were searched for releva...

I n 2000, the European Society of Cardiology and the American College of Cardiology presented new diagnostic criteria for myocardial infarction (MI) which placed a greater emphasis on cardiac markers by stating that any elevation in cardiac troponin T (cTnT) or cardiac troponin I (cTnI) above the 99th centile of normal was sufficient to diagnose a MI. Recent studies since then have shown that t...

Creatine kinase-MB (CK-MB) and troponin I elevations after successful percutaneous coronary intervention (PCI) are common, and different gradations have been correlated with mortality. To establish which of these 2 markers of myonecrosis, CK-MB and troponin I, accurately predicts mortality after successful PCI, we analyzed 2,873 patients without acute myocardial infarction who underwent PCI for...

To diagnose a myocardial infarction, an increase and/or fall in troponin values by at least one value > the 99th percentile in a healthy reference population is required, combined with other ischaemic signs or symptoms (1). Troponin T and troponin I are considered equal in diagnostics of myocardial infarction. There is only one manufacturer of tests for troponin T and thus only one reference ra...