BACKGROUND Patients with chronic kidney disease (CKD) are associated with increased cardiovascular morbidity and mortality. An increase in the ratio of pre-ejection period (PEP) to ejection time (ET) is correlated with an increase in left ventricular mass index (LVMI) and a decrease in left ventricular ejection fraction (LVEF). Brachial PEP (bPEP) and brachial ET (bET) can be automatically dete...

During the adaptive phase of an immune response, naive B cells receive multiple signals to become activated. Among them are the engagement of the B cell Ag receptor and stimulation by cytokines. Specifically for an anti-microbial response, the recognition of viral or bacterial Ags by the BCR and the stimulation of IFN-gamma result in the predominant production of IgG2a. The T-bet protein has be...

Nitration of pollen derived allergens can occur by NO(2) and ozone in polluted air and it has already been shown that nitrated major birch (Betula verrucosa) pollen allergen Bet v 1.0101 (Bet v 1) exhibits an increased potency to trigger an immune response. However, the mechanisms by which nitration might contribute to the induction of allergy are still unknown. In this study, we assessed the e...

BACKGROUND/AIMS T-bet, a member of the T-box family of transcription factors, is a key marker of type I immune response within the tumor microenvironment, and has been previously reported by us to serve as an important prognostic indicator for human gastric cancer patients and a potential biomarker for immunotherapy. In the present study, we aimed to assess the clinical significance and prognos...

There is presently a lack of knowledge of scour progression for complex offshore foundation structures, such as Tripod foundations for offshore wind turbines. Typically, scour is investigated in physical model tests. As an extension, parts of the investigations could be carried out by using numerical methods; however, such numerical methods require that all relevant processes leading to scour a...

Distinct electromagnetic properties can emerge from the three-dimensional (3D) configuration of a plasmonic nanostructure. Furthermore, the reconfiguration of a dynamic plasmonic nanostructure, driven by physical or chemical stimuli, may generate a tailored plasmonic response. In this work, we constructed a 3D reconfigurable plasmonic nanostructure with controllable, reversible conformational t...

the undesirable effects and consequences of occupational fatal accidents have placed a great emphasis on applying preventive measures. this study was aimed to analyze and specify the latent causes of occupational fatal accidents in exir chemical plant, urmia - iran in 2008-2009. the analytical tripod-beta method was used. a geographic information system (gis) was then used to determine a list o...

theorization in sociological literature in general and in sociology of the family in particular suffers from conceptual confusion. the proposer of the concept: “iranian tripod system” tries to analyze the family situation and its changes in iran through modernity. the present paper studies the conceptual framework of iranian tripod system and its related quadrilateral concepts: “iranian society...

Bromodomain and extraterminal (BET) domain proteins have emerged as promising therapeutic targets in glioblastoma and many other cancers. Small molecule inhibitors of BET bromodomain proteins reduce expression of several oncogenes required for Glioblastoma Multiforme (GBM) progression. However, the mechanism through which BET protein inhibition reduces GBM growth is not completely understood. L...