A new approach to platencin, a potent antibiotic isolated from Streptomyces platensis, has been established. The highly congested tricyclic core of the natural product was successfully constructed by decarboxylative radical cyclization of an alkynyl silyl ester with Pb(OAc)4 in the presence of pyridine in refluxing 1,4-dioxane. The key decarboxylation, which likely takes place via lead(IV) este...

Background In order to mitigate potential issues with antibiotic resistance in the treatment of patients with Helicobacter pylori infection, the selection of a therapeutic regimen is optimized by being aware of local eradication rates as well as the patient's medication history and previous diagnoses. Purpose This study primarily aimed to calculate the eradication rate of H. pylori infection ...

BACKGROUND H.pylori (H.p.) infection of the gastric mucosa is causally related to chronic gastritis, peptic ulcer disease, MALT-lymphoma and gastric cancer. There is also an evidence for a link between the H.p.-infection and non-ulcer dyspepsia and even extragastric diseases. The number of patients treated against H.p. infection is expanding. Although in the last years the PPI-based triple ther...

The known factors that have contributed to the decline of Helicobacter pylori (H. pylori ) eradication rate include antibiotic resistance, poor compliance, high gastric acidity, high bacterial load, and cytochrome P450 2C19 (CYP2C19) polymorphism. Proton pump inhibitor (PPI) is important in the eradication regimen. The principal enzyme implicated in the metabolism of PPIs is CYP2C19. The effect...

as a generalization of the triple i method, the universal triple imethod is investigated from the viewpoints of both fuzzy reasoningand fuzzy controller. the universal triple i principle is putforward, which improves the previous triple i principle. then,unified form of universal triple i method is established based onthe (0,1)-implication or r-implication. moreover, the reversibilityproperty o...

Conjugate vaccines have reduced pneumococcal disease in vaccinated children and unvaccinated adults, but non-vaccine serotypes are of concern, particularly if antibiotic resistant. We reviewed Streptococcus pneumoniae collected via: (i) the British Society for Antimicrobial Chemotherapy (BSAC) surveillances from 2001-2014; (ii) Public Health England's (PHE) invasive isolate surveillance from 20...

Helicobacter pylori infection is the most common infection worldwide and is associated with simple dyspepsia, heartburn and peptic ulcer diseases, most commonly leading to upper gastrointestinal bleeding and, ultimately, to the severe complication of gastric malignancy. Ninety percent of duodenal ulcers and 70% of gastric ulcers are associated with helicobacter pylori infections. Noninvasive me...

The association of internal root resorption (IRR) with dens invaginatus is an extremely rare finding, and its incidence may be underestimated, adding to the difficulty endodontic treatment. A 9-year-old boy was admitted complaints swelling pain. Radiological examination revealed closed apex Oehlers type II severe IRR, as well apical third two lateral perforation lesion. Calcium hydroxide applie...

The inappropriate use of antibiotics contributes to the development resistant bacteria and has a significant influence on treatment failure. increasing rapid spread ABR (Antibiotic Resistance) become big issue through worldwide during past few decades. main objective is identify most prescribing in clinical practice. To evaluate pattern for different microbial infection. It prospective observat...