To investigate the possibility that anticancer drugs combined with cytokines may show increased activity, human tumor cells were treated with combinations of human recombinant interleukin la (rIL-la) and etoposide (VP-16). The cytotoxicity of these combinations was evaluated by the 3-(4,S-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide as say using rIL-la-sensitive A375-C6 melanoma cells...

4 Virtual bidding is a financial mechanism that allows participants to speculate on the price spread 5 between day-ahead and real-time wholesale electricity markets. We employ statistical learning methods 6 to show that virtual bidding improves financial efficiency by narrowing the room for arbitrage. We 7 then formulate a two-settlement market model and use it to analyze market data. We find t...

The uptake of 67Gaby HL60 cells requires binding of 67Ga-transferrin (TO to cell surface Tf receptors. To further examine this process, we have studied early events in the cellular uptake of 67GaTf. Cell surfacebound "~(.;i11 and '"loll displayed similar kinetics during the first 10 min of uptake. Thereafter, approximately 10% of intracellular 67Gawas released by cells while 59Fe internalizatio...

Imagine a robot that is executing a program on line and insofar as it is reasonable to do so it wishes to continue with this on line program execution no matter what exoge nous events occur in the world Execution monitoring is the robot s process of observ ing the world for discrepancies between the actual world and its internal representation of it and recovering from such discrepancies We pro...

Previous research on machine discovery has focused on limited parts of the empirical discovery task. In this paper we describe IDS, an integrated system that addresses both qualitative and quantitative discovery. The program represents its knowledge in terms of qualitative schema*, which it discovers by interacting with a simulated physical environment. Once IDS has formulated a qualitative sch...

s of the 214th ACS National Meeting.20. Dong, J., S. Iuchi, H. S. Kwan, Z. Lu, and E. C. Lin. 1993. The deducedamino-acid sequence of the cloned cpxR gene suggests the protein is thecognate regulator for the membrane sensor, CpxA, in a two-component signal transduction system of Escherichia coli. Gene 136:227–230.21. Dziejman, M., and J. J. Mekalanos. 1995. Two-component signal ...

ion also makes use of a model of the world and can be viewed as a deliberative approach to solve reasoning tasks. As an antithesis to this classical AI paradigm (and in particular to the planning paradigm) an approach has been developed that explicitly does not make use of knowledge representation and complicated deliberations (such as planning the best next step in the proof search). Brooks ph...

code component. A pattern represents the core of a solution to similar recurring problems, comprising a general arrangement of classes/objects (Gamma et al. 94). Design patterns are more abstract design elements than frameworks (they may be applied in the construction and design of a framework) and their architectural granularity is ner. The activity is a modelling and programming mechanism tha...