........................................................................................................................................ iii PUBLIC ABSTRACT ......................................................................................................................... v ACKNOWLEDGMENTS .......................................................................................................

At a given external dose of an inhaled chemical the internal dose or the amount absorbed into the body varies depending on pulmonary ventilation and other physiological factors. Such variability is of concern in the development of biological indices of occupational exposure to organic solvent vapours. This paper discusses how physiological factors may influence the pharmacokinetic behaviour of ...

Small, volatile hydrocarbons, including trichloroethylene, vinyl chloride, carbon tetrachloride, benzene, and chloroform, are common environmental pollutants that pose serious health effects. We have developed transgenic poplar (Populus tremula x Populus alba) plants with greatly increased rates of metabolism and removal of these pollutants through the overexpression of cytochrome P450 2E1, a k...

Subanaesthetic concentrations of ether, trichloroethylene, cyclopropane and nitrous oxide can provide analgesia (Dundee, Nicholl and Black, 1962). This property of ether (Artusio, 1955) and cyclopropane (Sheiner, 1958) has been applied to the production of analgesia for surgical procedures but only nitrous oxide and trichloroethylene have been used for postoperative analgesia. Nitrous oxide has...

Ogata, M., Takatsuka, Y., and Tomokuni, K. (1970). Brit. J. industr. Med., 27, 378-381. A simple method for the quantitative analysis ofurinary trichloroethanol and trichloroacetic acid as an index of trichloroethylene exposure. A simple method of estimating trichloroethanol and trichloroacetic acid in the urine of workers exposed to trichloroethylene is described. The glucuronide of trichloroe...

Volatile organic compounds (VOC) are present at over two-thirds of Superfund, Resource Conservation and Recovery Act of 1976 (RCRA), and U.S. Department of Defense sites (EPA 1996). Thus, remediation of VOCs is a top concern to the Environmental Protection Agency. Trichloroethylene (TCE) is a persistent VOC contaminant that infiltrates soil and ground water from improper disposal of dry cleanin...