نتایج جستجو برای: tricarboxylic acid cycle
تعداد نتایج: 999374 فیلتر نتایج به سال:
Succinate is an interesting chemical for industries producing food and pharmaceutical products, surfactants, detergents and biodegradable plastics. Succinate is produced mainly by a mixed-acid fermentation process using anaerobically growing bacteria. However, succinate excretion is also widespread among fungi. In this article we report results on the intracellular concentration and the excreti...
A mutant of Bacillus subtilis 168 lacking aconitase (EC 4.2.1.3) was found to be blocked at stage 0 or I of sporulation. Although adenosine triphosphate levels, which normally decrease in tricarboxylic acid cycle mutants at the completion of exponential growth, could be maintained at higher levels by feeding metabolizable carbon sources, this did not permit the cells to progress further into th...
BACKGROUND Although myocardial oxidative tricarboxylic acid (TCA) cycle activity and contractile function are closely linked in normal cardiac muscle, their relation during postischemic reperfusion, when contractility often is reduced, is not well defined. METHODS AND RESULTS To test the hypothesis that oxidative TCA cycle flux is reduced in reperfused myocardium with persistent contractile d...
UNLABELLED A recent controversial hypothesis suggested that the bactericidal action of antibiotics is due to the generation of endogenous reactive oxygen species (ROS), a process requiring the citric acid cycle (tricarboxylic acid [TCA] cycle). To test this hypothesis, we assessed the ability of oxacillin to induce ROS production and cell death in Staphylococcus epidermidis strain 1457 and an i...
The inhibition of succinate oxidation by malonate is a well known phenomenon. Since the oxidation of succinate to fumarate is an integral part of the Krebs cycle of oxidations, it has been generally assumed that the inhibitory effect of malonate upon the oxidation of any member of the cycle is the result of the inhibition of the succinate to fumarate step. However, the present paper provides ev...
Is there tight channelling in the tricarboxylic acid cycle metabolon? Balazs Sumegi,§ A. Dean Sherry,§ Craig R. Malloy,*$ Claudia Evans*t and Paul A. Srere*t *Pre-Clinical Science Unit of the Department of Veterans Affairs Medical Center, tDepartment of Biochemistry and $The Mary Nell & Ralph B. Rogers N.M.R. Center, The University of Texas Southwestern Medical Center at Dallas, 4500 South Lanc...
In crude cell extracts of the ectomycorrhizal fungus, Suillus bovinus, activities of citrate synthase, aconitase, isocitrate dehydrogenase, succinate dehydrogenase, fumarase, and malate dehydrogenase have been proved and analyzed. Citrate synthase exhibited high affinities for both its substrates: oxaloacetate (Km = 0.018 mM) and acetyl-CoA (Km = 0.014 mM). Aconitase showed better affinity for ...
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