Thirteen difluoromethyl-containing pseudopeptides were synthesized by Ugi reaction using the novel building block 2,2-difluoro-2-(phenylthio)acetic acid (2) as one component, followed by removal of the phenylsulfanyl protecting group in the presence of tributyltin hydride and azobisisobutyronitrile.

The first total synthesis of clavaminol A and C, (2R,3S)-2-amino-3-alkanols from the Mediterranean ascidian Clavelina phlegraea has been achieved in 29% overall yield. The key step involved a palladium(II)-catalysed directed Overman rearrangement to create the C-N bond and install the erythro configuration while a one-pot, tributyltin hydride-mediated reduction allowed simultaneous formation of...

Tinnitus Research Initiative is dedicated to fi nd a cure for Tinnitus. In this context, we are delighted to present you this fi rst issue of the TRI NEWSLETTER. We hope that this newsletter, will facilitate collaboration and knowledge sharing between supported institutions and interest new stakeholders in order to develop our common network. We would like this newsletter to provide relevant ne...

A covalently triggered fluorescence turn-on detection scheme has been implemented for a tris(N-salicylideneamine)-derived dynamic fluorophore. Selective cleavage of strategically placed Si-O bonds by fluoride ion induces spring-loaded conformational transitions that are tightly coupled to fluorescence enhancement.

Let $mathfrak{A}$ be an algebra. A linear mapping $delta:mathfrak{A}tomathfrak{A}$ is called a textit{derivation} if $delta(ab)=delta(a)b+adelta(b)$ for each $a,binmathfrak{A}$. Given two derivations $delta$ and $delta'$ on a $C^*$-algebra $mathfrak A$, we prove that there exists a derivation $Delta$ on $mathfrak A$ such that $deltadelta'=Delta^2$ if and only if either $delta'=0$ or $delta=sdel...

We have developed a three level implicit method for solution of the Helmholtz equation. Using the cubic spline in space and finite difference in time directions. The approach has been modied to drive Numerov type nite difference method. The method yield the tri-diagonal linear system of algebraic equations which can be solved by using a tri-diagonal solver. Stability and error estimation of the...

OBJECTIVE The prognostic value of the Global Registry of Acute Coronary Events (GRACE) risk score (GRS) and the Thrombolysis In Myocardial Infarction (TIMI) risk index (TRI) has been reported in coronary artery disease (CAD) patients. We aimed to evaluate the relationship between the GRS, TRI, and severity of CAD evaluated by SYNTAX score (SS) in patients with acute coronary syndrome (ACS). M...

Studies using animal models demonstrated the importance of autocrine/paracrine factors secreted by preimplantation embryos and reproductive tracts for embryonic development and implantation. Although in vitro fertilization-embryo transfer (IVF-ET) is an established procedure, there is no evidence that present culture conditions are optimal for human early embryonic development. In this study, k...

Let $mathcal{A}$ be a Banach algebra and $mathcal{M}$ be a Banach $mathcal{A}$-bimodule. We say that a linear mapping $delta:mathcal{A} rightarrow mathcal{M}$ is a generalized $sigma$-derivation whenever there exists a $sigma$-derivation $d:mathcal{A} rightarrow mathcal{M}$ such that $delta(ab) = delta(a)sigma(b) + sigma(a)d(b)$, for all $a,b in mathcal{A}$. Giving some facts concerning general...