نتایج جستجو برای: tri and foursubstituted imidazoles derivatives

تعداد نتایج: 16849304  

Journal: :Clinical microbiology reviews 1988
R A Fromtling

Fungal infections are a major burden to the health and welfare of modern humans. They range from simply cosmetic, non-life-threatening skin infections to severe, systemic infections that may lead to significant debilitation or death. The selection of chemotherapeutic agents useful for the treatment of fungal infections is small. In this overview, a major chemical group with antifungal activity,...

2011
Baskar Lakshmanan Papiya Mitra Mazumder Dinakar Sasmal Swastika

Cimetidine is the prototype antiulcer drug having the imidazole nucleus and acts by blocking histamine H2 receptors. Keeping this context in mind, an attempt has been made to study the antihistaminic activity of some novel 1-substituted imidazole derivatives on isolated guinea pig atria to reveal their desired pharmacological effects. In the present revision, some 1-substituted Imidazoles (1a-1...

2007
Hasan Tashtoush Yaseen Al-Soud Ahmed Maslat Mohanad Shkoor Mahmoud Al-Talib

A series of 5-sulphanyl derivatives of 1-Benzyl-2-alkyl-4-nitro-1H-imidazoles (5-9) were prepared by the coupling method of 3-(1-Benzyl-2-ethyl-4-nitro-1H-imidazole-5ylsulfanyl)propanoic acid (4) with appropriate amino acid ester hydrochloride, in the presence of hydroxybenzotriazole (HOBT) and DCC. Compounds (10-12) and (13) were similarly synthesized using appropriate amino alcohols, and 1-su...

2010
Mukesh C. Sharma Dharm V. Kohli Smita Sharma

Mukesh C. Sharma Dept. of Pharmaceutical Sciences, Dr.Hari Singh Gour University Sagar (M.P) 470003 India Department of Chemistry Yadhunath Mahavidyalya Bhind (M.P) 477001 India Email: [email protected] Abstract A new series of non peptide angiotensin (A-II) receptor antagonist has been prepared. This N-(biphenyl methyl) imidazoles e.g. Some new 4'-{5-amino2-[2-substituted-phenylamino)-ph...

2003
Varoujan A. Yaylayan Luke J.W. Haffenden

Studies with C-2-labelled glycine and alanine in model systems containing 2,3-butanedione, glyceraldehyde or glyoxal have indicated that imidazoles and oxazoles can be formed from a-dicarbonyl compounds through Strecker reaction and subsequent formation of a-amino carbonyl reactive intermediates. These intermediates can react with any aldehyde in the reaction mixture to form an imine which in t...

2013
Rakesh Kumar Mohd. Shahar Yar Saurabh Chaturvedi Atul Srivastava

In the previous years the synthesis of high nitrogen containing heterocyclic systems has been attracted to many pharmaceutical and agrochemical industries. The triazole nucleus is one of the most important heterocycles which is a feature of natural products and medicinal agents. Triazole nucleus is enjoying their importance as being the center of activity. The nitrogen containing heterocyclics ...

2010
Kevin Pethe Patricia C. Sequeira Sanjay Agarwalla Kyu Rhee Kelli Kuhen Wai Yee Phong Viral Patel David Beer John R. Walker Jeyaraj Duraiswamy Jan Jiricek Thomas H. Keller Arnab Chatterjee Mai Ping Tan Manjunatha Ujjini Srinivasa P.S. Rao Luis Camacho Pablo Bifani Puiying A. Mak Ida Ma S. Whitney Barnes Zhong Chen David Plouffe Pamela Thayalan Seow Hwee Ng Melvin Au Boon Heng Lee Bee Huat Tan Sindhu Ravindran Mahesh Nanjundappa Xiuhua Lin Anne Goh Suresh B. Lakshminarayana Carolyn Shoen Michael Cynamon Barry Kreiswirth Veronique Dartois Eric C. Peters Richard Glynne Sydney Brenner Thomas Dick

Candidate antibacterials are usually identified on the basis of their in vitro activity. However, the apparent inhibitory activity of new leads can be misleading because most culture media do not reproduce an environment relevant to infection in vivo. In this study, while screening for novel anti-tuberculars, we uncovered how carbon metabolism can affect antimicrobial activity. Novel pyrimidine...

Journal: :journal of sciences, islamic republic of iran 2014
s. rezayati s. sajjadifar

a mild and green method has been developed for the preparation of coumarins derivatives through the one-pot reactions. in our study,various phenols and ethyl acetoacetate compound in which we used silica-supported boron sulfonic acid [sio2/b(so4h)3] as a new, highly efficient and tri-functional inorganic brønsted acid catalyst were processed under solvent-free condition and thermal. the catalys...

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