Group A streptococcus (GAS) is a common pathogen of the human skin and mucosal surfaces capable of producing a variety of diseases. In this study, we investigated regulation of iron uptake in GAS and the role of a putative transcriptional regulator named MtsR (for Mts repressor) with homology to the DtxR family of metal-dependent regulatory proteins. An mtsR mutant was constructed in NZ131 (M49...

background helicobacter pylori is responsible for one of the most common human infections and is a major risk factor for stomach ulcer disease and gastric cancer. h. pylori infection has been reported to be associated with generation and development of coronary artery disease (cad). moreover, diabetic patients positive for h. pylori infection showed a higher prevalence of cad compared to h. pyl...

BACKGROUND Crimean-Congo hemorrhagic fever was rarely reported from Iran before 1999. In a recent outbreak, the disease has been reported from different provinces of Iran, especially from Sistan and Baluchestan. Ribavirin has been recommended by World Health Organization as a potential therapeutic modality for Crimean-Congo hemorrhagic fever. This study was conducted to determine the clinical o...

Abstract Although antibiotics are clinically crucial, little is known about how they impact a patient’s immune response to infection. We address that gap by investigating macrophages respond bacteria treated with different classes of antibiotics. broadly susceptible E. coli strain 8 separate antibiotics, infected macrophages, and compared much TNF the various antibiotic-treated elicited from ma...

Escherichia coli O157:H7 (O157) is a Gram negative and highly virulent bacteria found in food and water sources, and is a leading cause of chronic diseases worldwide. Diagnosis and prevention from the infection require simple and rapid analysis methods for the detection of pathogens, including O157. Endogenous membrane peroxidase, an enzyme present on the surface of O157, was used for the color...

In 72 episodes of suspected or proven Hickman-catheter-associated infection occurring in 59 patients with various hematological disorders, patients were assigned to treatment with either vancomycin or teicoplanin in a randomized nonblinded prospective study. Of 60 episodes evaluable for response, 28 were treated with vancomycin and 32 were treated with teicoplanin. Sixteen infective episodes we...

BACKGROUND Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections induce robust, generalized inflammatory responses that begin during acute infection and lead to pathological systemic immune activation, fibrotic damage of lymphoid tissues, and CD4⁺ T-cell loss, pathogenic processes that contribute to disease progression. METHODS To better understand the contribu...

IIn this study, the effects of paraxanthin on lettuce were investigated. Paraxanthin is a group of purine alkaloids, secondary metabolites of plants. This compound is made up of the caffeine metabolism found in plants such as tea, coffee and cocoa. There have been previous reports of paraxanthine antihypertensive properties.Three different concentrations of paraxanthine as 10, 50 and 100 µg/ml ...

Background: .
 Malaria is serious vector –borne tropical diseases that remains one of the primary reasons for death in several countries . and typhoid co-infection a major public health problem many developing countries. Most co-infections treated are based on methods diagnosis plagued with assumptions which possibly exaggerate situation. Objective: This aim this work was to investigate ra...

SoxR is a global regulator contributing to multidrug resistance in Enterobacteriaceae. However, the contribution of SoxR to antibiotic resistance and fitness in Acinetobacter baumannii has not yet been studied. Comparisons of molecular characteristics were performed between 32 multidrug-resistant A. baumannii isolates and 11 susceptible isolates. A soxR overexpression mutant was constructed, an...