background: diabetic retinopathy is the major cause of blindness among working-age population across the world. despite the urgent need for research strategic planning in this field, no systematic research has been previously performed analyzing the published research on diabetic retinopathy. the study aimed to analyze the scientific productions on dr for drawing a general roadmap for future re...

Hsing-Jien Kung,1,2,3,4,*,y Chun A Changou,2,3,y Chien-Feng Li, and David K Ann Department of Biochemistry &Molecular Medicine; UC Davis Comprehensive Cancer Center; Sacramento, CA USA; Integrated Laboratory; Center of Translational Medicine; Taipei Medical University; Taipei, Taiwan, Republic of China; Graduate Institute of Translational Medicine; Taipei Medical University; Taipei, Taiwan, Rep...

Science encompass a broad spectrum of research, connecting basic discoveries that ultimately improve human health to community-based epidemiologic, and health services studies ( Figure 1 ). Th e relationships and fl ow of knowledge are reciprocal among the translational areas. Translational Science’s unifying hallmark theme is commitment to apply scientifi c methodologies effi ciently and to im...

1Lung Innate Immunity Research Laboratory, Program in Physiology & Experimental Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada M5G 0A4 2Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada M5G 0A4 3Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada M5S 1A8 4Department of Translational Pulmonology, D...

The approval of new medicines has slowed significantly over the past years. In order to accelerate the development of new compounds, novel approaches in drug development are required. Translational medicine or research, an emerging discipline on the frontier of basic science and medical practice, has the potential to enhance the speed and efficiency of the drug development process through the u...

Major scientific advances in basic science, pharmacology, and translational medicine have allowed the discovery of new molecular targets whose manipulation by new chemical entities has led to treatments for inflammatory diseases, including rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. Development of new agents for systemic lupus erythematosus (SLE) has lagged, howeve...

This issue of MHR contains six papers outlining and discussing the current state of our knowledge about male germ-cell DNA including the packaging of DNA during spermatogenesis and its unpacking in the oocyte, assessment of DNA damage in the male germ line and the consequences of this damage upon early embryo development and the subsequent generations. As is the nature of New Research Horizons ...