We report on a systematic study of upconverting fluorescence signal generation within turbid phantoms and real tissues. An accurate three-point Green's function, describing the forward model of photon propagation, is established and experimentally validated. We further demonstrate, for the first time to our knowledge, autofluorescence-free transillumination imaging of mice that have received bi...

In early stages of rheumatoid arthritis some changes in joints arise due to an inflammatory process. In the case of transillumination with near infrared light these changes affect the radiation transport in joints. We performed first numerical simulations for a basic approach of a sagittal optical tomographic imaging method that led to promising results. For this purpose, the optical properties...

The recently introduced time-resolved technique for enhanced medical transillumination imaging has been demonstrated for the important case of a diode laser transmitter. This type of gated-viewing technique utilizes early received light only to reject multiply scattered, delayed light, normally blurring the image. Human breast-cancer detection is demonstrated in vitro, and the observations are ...

A time-gated technique to improve the possibility of localizing spatial differences in absorption when transilluminating a turbid, highly scattering medium, such as human tissue, is demonstrated. When transmitting picosecond laser pulses and detecting photons on the opposite side of the object, the contrast can be strongly enhanced by detecting only the photons with the shortest traveling time....

Transillumination in the diagnosis of breast disease was first used about 50 years ago.'-3 The sinus diaphanograph is a recent development that provides a light beam of variable intensity. When it is used at the lowest possible setting small lesions become capable of light interference and more subtle changes in tissue density can be visualised. Diaphanoscopy is performed in a totally darkened ...