Therapeutic agents, in general, undergo chemical alteration in the body to form derivatives of the parent compound. Isolation and pharmacological assay of the various transformation products may yield valuable information in the Senrch for better therapeutic agents, in studies on the mechanism of drug action :,*d in the elucidation of norm+l metabolic processes. The therapeutic effect of a drug...

Product longevity is a key to improving the sustainability of production and consumption patterns. However, at many companies, extending product requires overcoming several complex barriers. Identifying how begin this process can be difficult; moreover, available solutions may seem too or radical and, therefore, ignored as viable options. The purpose paper study approaches decision patterns tha...

A number of years ago several investigators f published independently this theorem : Any screw motion—the most general mechanical motion of space —can be decomposed into the product of two semi-rotations. By a semi-rotation is meant that transformation which consists of rotating space through 180° about a fixed axis I. For generalizing however it is more convenient to look at this transformatio...