Transdermal drug delivery has made a notable contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. While transdermal delivery systems would appear to provide an attractive solution for local and systemic drug delivery, only a limited number of drugs can be delivered through the outer layer of the skin. The most...

OBJECTIVES The primary objective of this multicentre, prospective, observational study was to assess whether there is improvement in the patients' quality of life under treatment with rivastigmine transdermal patch, as it is evaluated both by patients and their caregivers. Compliance to treatment and safety were secondary endpoints. METHODS In total, 1509 patients with mild to moderate Alzhei...

The purpose of the present study was to develop a novel transdermal drug-delivery system comprising a polyamidoamine dendrimer coupled with sonophoresis to enhance the permeation of diclofenac (DF) through the skin. The novel transdermal drug-delivery system was developed by using a statistical Plackett-Burman design. Hairless male Wistar rat skin was used for the DF-permeation study. Coupling ...

background and aims: one of the problems with the implementation of spinal anesthesia is not to achieve an appropriate sensory level and sensory level decline before the end of operation that can cause pain and stress for the patient and surgeon dissatisfaction.                                                                                              in this study, the effects of transdermal...

Alendronate is a nitrogen-containing bisphosphonate that is widely used for the treatment of osteoporosis in postmenopausal women. However, the oral bioavailability (BA) of alendronate is approximately 0.9 to 1.8%. In addition, the oral administration of alendronate has been associated with mucosal damage including gastritis, gastric ulcer, and erosive esophagitis. To prevent these adverse effe...

Proliposomes are an innovative kind of carrier-mediated drug delivery that offers numerous advantages over traditional liposomes. The conventional liposomes susceptible to oxidation or hydrolysis, as well sedimentation, aggregation, fusion with other substances. While, proliposomes far more stable than liposomes, making them better suited for the pharmaceuticals. They a dry, free-flowing, granu...

AIM The feasibility of transdermal delivery of naloxone, an opioid antagonist, by anodal iontophoresis patches using Ag/AgCl electrodes was investigated. METHODS To examine the effect of current strength, species variation and drug concentration on skin permeability of naloxone, in vitro skin permeation studies were performed using rat dorsal skin and porcine ear skin as the membrane. To dete...

The aim of the current investigation is to evaluate the transdermal potential of novel vesicular carrier, ethosomes, bearing aceclofenac, Non-steroidal antiinflammatory drugs (NSAIDs) agents having limited transdermal permeation. Aceclofenac loaded ethosomal carriers were prepared, optimized and characterized for vesicular shape and surface morphology,(SEM) scanning electronic microscopy, vesic...