نتایج جستجو برای: transcription factor brn4
تعداد نتایج: 980024 فیلتر نتایج به سال:
retinal pigment epithelium is responsible for maintaining the structural integrity of the retina by an efficient defense against free radicals, photo-oxidative exposure and light energy. for this purpose the main rpe line of defense is melanosomes. melanin content of retinal pigment epithelium cells in adults and neonates reveals remarkable variations. in the current study we compared melanogen...
نوروتروفین ها بقاء، تمایز، رشد و آپوپتوزیز نورون ها را به وسیله اتصال به رسپتورهای سطحی رسپتور تیروزین کینازی trk میانجی گری می کنند. یکی از این رسپتور ها، رسپتور تیروزین کیناز b (trkb) است. trkb (tyrosine kinase b) رسپتوری برای neurotrophin 4/5 و bdnf (brain derived neurotrophic factor) است. در موش ژنtrkb بر روی کروموزوم 13 قرار دارد و چهار ایزوفورم پروتئینی بزرگ trkb+، trkb-t1، trkb-t2 وtrkb-...
Background: Elevated level of plasma homocysteine has been related to various diseases. Patients with hyperhomocysteinemia can develop hepatic steatosis and fibrosis. We hypothesized that oxidative stress induced by homocysteine might play an important role in pathogenesis of liver injury. Also, the cellular response designed to combat oxidative stress is primarily controlled by the transcripti...
Background: Colorectal cancer (CRC) is the fourth leading cause of cancer-caused death around the world. Reports of the unnecessary transcription of family genes of the fibroblast growth factor in several types of cancer indicate the role of these factors in tumorgenesis and progression of cancer. Therefore, the level of FGF11 transcription was evaluated in colorectal cancer tumor tissues relat...
Abnormal Mesenchymal Differentiation in the Superior Semicircular Canal of Brn4/Pou3f4 Knockout Mice
Numerous studies have demonstrated the importance of altered gene expression in disease pathophysiology. Thus, modification of gene expression has emerged as an important therapeutic strategy.1 Agents that inhibit the transcription of disease-mediating genes or transactivate the expression of genes whose products disrupt pathophysiological processes are being developed. Regulation of gene expre...
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