Alprazolam is a hypnotic/tranquilizer that has been shown to specifically inhibit the platelet-activating factor (PAF)-induced aggregation of human platelets. The goal of this study was to elucidate whether alprazolam modulates IL-1alpha-initiated responses. For this purpose we investigated the effects of alprazolam on the IL-1alpha-induced production of inflammatory cytokines (IL-8 and monocyt...

OBJECTIVES While the recreational use of prescription medications is widely recognized as a growing public health issue, there are limited epidemiological studies on patterns of use in Canada, particularly studies identifying populations at highest risk. The objective of this study was to describe recreational prescription drug use among Canadian adolescents by age, sex, socio-economic, immigra...

Background In recent years, ketamine has been the most used sedative in Emergency Department (ED) procedures for pain management. Therefore, this study evaluated ketamine associated vomiting (KAV) in children requiring sedation. Materials and Methods This is a prospective, randomized, and open trial study carried out on children of ages 3 months to 13 years requiring sedation for medical diagn...

VVhere the parents were relying upon the child's symptoms to support their own difficulties, the improvement can be disruptive. Hence the physician must have some understanding of the fam-ily's interactions to adequately predict the outcome of drug administration, and the family must be alerted to the probable changes. Considering all of the above, giving a tranquilizer becomes a rather broad a...

Hepatic Encephalopathy (HE) is an extra-hepatic complication of liver dysfunction manifested by neuropsychiatric features associated with acute or chronic liver disease, after exclusion of other known brain diseases. There are various factors which can precipitate HE. The purpose of this study was to identify precipitating factors of HE in liver cirrhosis patients at Liaquat University Hospital...

The concept of the self has been used in several attempts to resolve the epistemological problems of what is subjective and what is objective, what is personal and what is organismic. In addition, it has been used to mediate between the hermeneutic and natural-science approaches to psychoanalytic explanation, between the motivational and causal dimensions of our theory and experience. In the ca...