In an aging population, the decline in muscle mass and strength in combination with a high prevalence of osteoporosis and cancer leads to a multitude of clinical manifestations. In the recent years, mouse models of wasting in cancer and inflammation, including xenograft, genetic and chemically induced models, allowed to uncover several key mechanisms underlying muscle loss. These include inflam...

TRAF6 is critical for the production of inflammatory cytokines in various TLR-mediated signalling pathways. However, it is poorly understood how TRAF6 regulates TLR3 responses. Here we demonstrate that GSK3b interacts with TRAF6 and positively regulates the TLR3-mediated signalling. Suppression of GSK3b expression or its kinase activity drastically reduces the production of inflammatory cytokin...

BACKGROUND In response to viral infection, the innate immune system recognizes viral nucleic acids and then induces production of proinflammatory cytokines and type I interferons (IFNs). Toll-like receptor 7 (TLR7) and TLR9 detect viral RNA and DNA, respectively, in endosomal compartments, leading to the activation of nuclear factor kappaB (NF-kappaB) and IFN regulatory factors (IRFs) in plasma...

Tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) is an adapter protein that links signals from members of the TNFR superfamily and Toll/IL-1 receptor family to activation of transcription factors NFkappaB and AP-1. Analysis of TRAF6-deficient mice revealed that TRAF6 is essential for normal bone formation and establishment of immune and inflammatory systems. Here we report that...

Tumor necrosis factor receptor-associated factor 6 (TRAF6) is an important E3 ubiquitin ligase, which is key to immunity. TRAF6 has been implicated in the invasive growth and metastasis of various types of cancer, including squamous cell carcinoma, gastric cancer, myelodysplastic syndromes and acute myeloid leukemia. In the present study, associations between multiple myeloma (MM) and TRAF6, it...

BACKGROUND Tumor necrosis factor receptor-associated factor 6 (TRAF6) has been reported to be highly expressed in many tumor tissues, but it is still of value to detect its expression in patients with colon cancer and to clarify its clinical significance. OBJECTIVES To study the expression and clinical significance of TRAF6 in patients with colon cancer. PATIENTS AND METHODS A total of 135 ...

TRAF6 is an E3 ubiquitin ligase that mediates signaling from members of the tumor necrosis factor and Toll-like receptor superfamilies, including the p75 neurotrophin receptor. Recently, TRAF6 was shown to bind to another p75 cytoplasmic interactor, NRIF, and promote its nuclear localization. Here, we demonstrate that NRIF is a substrate for TRAF6-mediated K63 polyubiquitination and that this m...

This paper reports findings from an AHRC-funded project into the use of more than one language in research projects. Using 35 seminar presentations and 25 researcher profiles, we investigated how researchers from differing disciplines became aware of the possibilities, complexities, and emerging practices of researching where more than one language is used: for example, in initial research desi...

Variations of heavy metals concentrations (Pb, Zn, Ni and Cd) in suspended matter as well as the physical properties (temperature, salinity, dissolved oxygen and pH) at five coastal sites and one reference station (offshore) were measured on seasonal base of the year 2005. Seasonal variations of seawater temperature, salinity, pH and dissolved oxygen were significant different, meanwhile; spati...

ت ُـ ا ةيباسحلا جماربلا لامعتسا نع ةجتانلا ةيلعافلا سايقل ةيّقيبطت تانوّكم ةساردلا هذه ددّح ةعوفدمل ةيتامولعم ةيمآ دوجوب يبيرقتلا قطنملا ةيرظن ىلع ةزكترملا هيجوتلاو ةرطيسلا ةمظنأ ةسدنه ىلإ ةفداه . نإ اعم دوجوب اهلامعتسا لجلأ ةهجوم ةيّسايقلا تانوّكملا ةيطّخ ريغو ةدقعم ةيباسح تلاد . و ثحبت ةساردلا هذه نم ةيّسايقلا تانوّكملا لامعتسا يف اهدامتعا بجاولا ةقيرطلا يف اًضيأ أ نم فلتخم ددع نيب ليضفتلا لج تامولعملا...