Selenium is an essential trace element, the deficiency of which is associated with an increased incidence of some human cancers. Dietary supplementation with selenium has been reported to produce a decrease in the incidence of some cancers in humans. Thioredoxin reductase (TR) is a newly discovered homodimeric selenocysteine (SeCys)-containing protein that catalyzes the NADPH-dependent reductio...

Thyroid hormones, T4 and T3, regulate their own production by feedback inhibition of TSH and TRH synthesis in the pituitary and hypothalamus when T3 binds to thyroid hormone receptors (TRs) that interact with the promoters of the genes for the TSH subunit and TRH. All TR isoforms are believed to be involved in the regulation of this endocrine axis, as evidenced by the massive dysregulation of T...

Thyroid hormone acts in virtually every biological system in vertebrates by controlling the expression of different sets of genes. To achieve this, thyroid hormone interacts with two receptors (TR), TR and TR , located in the nucleus of its target cells, which turn gene transcription on or offand thusmediate thebiological effectsassociatedwith the thyroid secretion (1, 2). The distribution of T...

To study the usefulness of glycerin fatty acid ester Poem TR-FB (TR-FB) and Poem TR-HB (TR-HB) as lubricants, pressure transmission ratio, ejection force, disintegration time, and tensile strength were measured at different concentrations and mixing times for granules and tablets. When each lubricant was mixed at 0.1-3.0%, the increase in the pressure transmission ratio that was equal to or gre...

BACKGROUND Tricuspid regurgitation (TR) is regarded as a secondary disorder. Aim of the study was to know what percentage is secondary to heart and lung disease and its prevalence in normal adults. METHODS Two hundred and 30 adults with clinically detectable TR were studied clinically to know the cause of TR. RESULTS Thirteen percent of the adults were normal without any detectable cause fo...

Understanding the basis of the binding of a T cell receptor (TR) to the peptide-MHC (pMHC) complex is essential due to the vital role it plays in adaptive immune response. We describe the use of computed binding (free) energy (BE), TR paratope, pMHC epitope, molecular surface electrostatic potential (MSEP) and calculated TR docking angle (θ) to analyse 61 TR/pMHC crystallographic structures to ...

A flat of a matroid is cyclic if it is a union of circuits; such flats form a lattice under inclusion and, up to isomorphism, all lattices can be obtained this way. A lattice is a Tr-lattice if all matroids whose lattices of cyclic flats are isomorphic to it are transversal. We investigate some sufficient conditions for a lattice to be a Tr-lattice; a corollary is that distributive lattices of ...

Answering a question raised by S. Friedland, we show that the possible eigenvalues of Hermitian matrices (or compact operators) A, B, and C with C ≤ A+B are given by the same inequalities as in Klyachko’s theorem for the case where C = A + B, except that the equality corresponding to tr(C) = tr(A) + tr(B) is replaced by the inequality corresponding to tr(C) ≤ tr(A) + tr(B). The possible types o...

Pacemaker (PM) induced tricuspid regurgitation (TR) is a common echocardiographic finding. Although mild or moderate TR is frequently observed, severe TR is rare. We report the exceptional observation of a severe TR due to leaflet malcoaptation occurring late after PM implantation and in the following weeks after an aortic valve replacement. Our hypothesis is that the aortic valve surgery has b...