Trazodone is a selective antagonist and serotonin reuptake inhibitor used in medicine to treat anxiety. Toxicological studies of trazodone succinate were carried out on the basis Department Pharmacology Veterinary Faculty Stavropol State Agrarian University, Russia.
 The results obtained study acute toxicity drug Express Uspokoin® tablets allow us identify new as belonging moderately dange...

Human and animal toxicology has had a profound impact on our historical and current understanding of air pollution health effects. Early animal toxicological studies of air pollution had distinctively military or workplace themes. With the discovery that ambient air pollution episodes led to excess illness and death, there became an emergence of toxicological studies that focused on industrial ...

BACKGROUND In support of the Integrated Risk Information System (IRIS), the U.S. Environmental Protection Agency (EPA) completed a toxicological review of trichloroethylene (TCE) in September 2011, which was the result of an effort spanning > 20 years. OBJECTIVES We summarized the key findings and scientific issues regarding the human health effects of TCE in the U.S. EPA's toxicological revi...

Over the past decades, pharmaceutical companies have conducted a large number of high-quality in vivo repeat-dose toxicity (RDT) studies for regulatory purposes. As part of the eTOX project, a high number of these studies have been compiled and integrated into a database. This valuable resource can be queried directly, but it can be further exploited to build predictive models. As the studies w...

Explanation.................................................................................................. 256 Evaluation for acceptable daily intake......................................................... 256 Biochemical aspects............................................................................... 256 Absorption, distribution, and excretion ...........................................

microRNAs (miRNAs) are a large family of small regulatory RNA molecules found in all multicellular organisms. Since their discovery in 2001, there has been impressive progress in miRNA research, and a great deal is now known about the biosynthesis of miRNAs and their regulatory role in translation. It is becoming increasingly clear that miRNAs have fundamental roles to play in cellular response...

objective one of the prominent microorganisms in several reports of nosocomial infections is staphylococcus aureus (s. aureus) which is carried by several health care workers (hcw) many times throughout the day. the present investigation was conducted to assess the nasal and hand carriage rate of s. aureus amongst medical personnel of loghman hakim hospital's toxicological intensive care unit (...

Information concerning the fundamental mechanisms of action of both natural and environmental hormones, combined with information concerning endogenous hormone concentrations, reveals how endocrine-disrupting chemicals with estrogenic activity (EEDCs) can be active at concentrations far below those currently being tested in toxicological studies. Using only very high doses in toxicological stud...

SEURAT-1 is a European public-private research consortium that is working towards animal-free testing of chemical compounds and the highest level of consumer protection. A research strategy was formulated based on the guiding principle to adopt a toxicological mode-of-action framework to describe how any substance may adversely affect human health.The proof of the initiative will be in demonstr...

Recent developments in nanoparticle (NP) technology and their commercial production have raised concern regarding NP risk to health and the environment. The toxicological characteristics of NP may not be similar to that observed in pre-NP materials because of the enormous differences in size and surface area. Thus, careful risk evaluation studies are required. Since some NP have already been pr...