the excessive amounts of parathyroid hormone in secondary hyperparathyroidism (shpth) is suggested to interfere with normal erythropoiesis.  in shpth, during chronic renal failure, due to the impairment of erythropoietin synthesis, this effect is more pronounced.  in the present study the role of secondary hyperparathyroidism in the severity of anemia was evaluated in hemodialysis patients (n=3...

Iron overload in Africa was previously regarded as purely due to excessive iron in traditional beer, but we recently found evidence that transferrin saturation and unsaturated iron binding capacity may be influenced by an interaction between dietary iron content and a gene distinct from any HLA-linked locus. To determine if serum ferritin follows a genetic pattern and to confirm our previous ob...

objective febrile convulsions are prevalent in children aged between 9 months and 5 years, with an incidence of 2-5%. on the other hand, iron deficiency anemia is the most common hematologic disease of infancy and childhood with a period of incidence that coincides with the time of developing febrile convulsions. therefore, it is hypothesized that there is a possible association between these c...

Red meat consumption has been positively associated with colorectal cancer; however, the biological mechanism underlying this relationship is not understood. Red meat is a major source of iron, which may play a role in colorectal carcinogenesis via increased crypt cell proliferation, cytotoxicity, and endogenous N-nitrosation. In a nested case-control study within the Prostate, Lung, Colorectal...

BACKGROUND Iron deficiency is a proposed mechanism for the anemia that occurs in cats with chronic kidney disease (CKD). Minimal research investigating the iron status of these cats has been performed. OBJECTIVE To compare indicators of iron status in cats with CKD versus healthy cats and cats with nonrenal illness (NRI). To compare indicators of iron status in anemic versus nonanemic cats wi...

The purpose of this study was to determine whether Helicobacter pylori infection can contribute to growth deficit, especially in pubescent children who need large amounts of iron for growth. A structured questionnaire was sent to the parents of 532 healthy children aged 10 to 15 years (mean 12.9) to obtain demographic information on the parents and the environment. Of the 532 questionnaires sen...

The iron status and feeding practices of 434 infants in Vancouver were determined at 39 +/- 1 week of age. Iron-deficiency anaemia (haemoglobin < or = 101 g/L, or < or = 110 g/L with two or three abnormal results from tests of serum ferritin, zinc erythrocyte protoporphyrin and total iron binding capacity) occurred in 7% of infants. Low iron stores (serum ferritin < 10 micrograms/l) occurred in...

Circulating free iron is lethal. Humans have two circulating iron binding proteins to soak up free iron to prevent it from generating toxic quantities of free radicals. These proteins are transferrin, a highaffinity, low-capacity protein (2 atoms of iron per mole cule of transferrin) for which there are receptors on the surface of every iron-requiring cell; and ferritin, a lower-affinity, high-...

A growing body of literature supports the use of intravenous iron as a compliment to erythropoiesis stimulatory therapy and in a significant number of disease states where iron is necessary and oral iron is ineffective or not tolerated. The differences in efficacy, safety, and clinical nature of serious adverse events that occur with the various iron preparations are poorly understood. Misinter...

We aimed in this study to determine the changes due to hyperthyroidism or hypothyroidism in serum ferritin, iron, transferrin, vitamin Bn and erythrocytic parameters and to investigate the interrelationships between these parameters .Serum ferritin, iron, total iron-binding capacity (transferrin), vitamin B12, total andfree trüodothyronine (TT3 and FT3) , total andfree thyroxine (TT4 and FT4), ...