Purpose: This study aimed to evaluate the effects of topically applied water-in-oil (w/o) emulsion of Hippophae rhamnoides using standard R cutometer parameters. Methods: A w/o emulsion of 1 % hydro-alcoholic extract of H. rhamnoides (formulation) and placebo control (base) were used in the study. Eleven healthy male volunteers with a mean age of 24.5 years were selected after obtaining informe...

The aim of this study was to develop nanoemulsion containing soft extract of stem bark of Rapanea ferruginea to improve the topical delivery and anti-inflammatory activity. The extract of R. ferruginea stem bark was incorporated into the oily phase of the nanoemulsion by the method of phase inversion at low energy. The developed nanoemulsion had an average droplet size of 47.88±8.20 nm and a po...

the present study reports formulation of a traditionally used poly herbal product for wound healing and its chromatographic analysis by hptlc. herbal therapy was the common treatment prescribed by iranian physicians for wound healing. “zemad”, the most ancient pharmaceutical dosage form used in the iranian traditional medicine (itm) for skin diseases. in this study, a poly herbal paste (php) wi...

Borneol is a bicyclic monoterpenoid alcohol commonly used in traditional Chinese and Indian medicine. It is extracted from the essential oil of various medicinal plants. It has antibacterial, analgesic, and anti-inflammatory action proven in studies that used oral and intraperitoneal applications of this monoterpene in mice. The current study was designed to develop a topical gel formulation co...

PURPOSE The purpose of this study was to compare the aqueous humor concentrations of bimatoprost acid after topical instillation in rabbits of bimatoprost ophthalmic solution 0.01% and bimatoprost ophthalmic solution 0.03%, two commercially available intraocular pressure-lowering medications. METHODS Male Dutch Belted rabbits were divided into two teratment groups (four rabbits/eight eyes per...

The topical delivery of non-steroidal anti-inflammatory drugs (NSAIDS) such as Ibuprofen has been explored as a potential method of avoiding the first pass effects and the gastric irritation, which may occur when used orally. Ibuprofen is formulated into many topical preparations to reduce the adverse effects and simultaneously avoid the hepatic first-pass metabolism as well. However, it is dif...

Background. Topical treatment of cutaneous leishmaniasis is an attractive alternative avoiding toxicities of parenteral therapy while being administered through a simple painless route. Recently liposomal formulations of amphotericin B have been increasingly used in the treatment of several types of leishmaniasis. Aims. The efficacy of a topical liposomal amphotericin B formulation was compared...

Topical drug delivery is defined as the application of pharmaceutical dosage form to the skin for direct treatment of cutaneous disorder or the cutaneous manifestation of the general disease, with the intent of confining the pharmacological or other effect of the drug to the surface of the skin. Topical drug delivery systems include a large variety of pharmaceutical dosage form like semisolids,...

The present study aims to evaluate the topical anti-inflammatory activity of "Pinda thailam", a herbal gel formulation containing aqueous extract of roots of Rubia cordifolia (Rubiaceae) and Hemidesmus indicus (Asclepiadaceae) which are known for their anti-inflammatory activity using the technique of carrageenin induced paw oedema in albino rats. The herbal gel formulation showed significant a...