UNLABELLED Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy in need of more effective treatment approaches. One potential therapeutic target is Wnt/β-catenin signaling, which plays important roles in PDAC tumor initiation and progression. Among Wnt inhibitors with suitable in vivo biologic activity is vitamin D, which is known to antagonize Wnt/β-catenin signaling in colorect...

We have previously reported that by inducing calcium sensing receptor (CaSR), calcitriol, the active form of vitamin D, promoted the sensitivity of the human colon carcinoma cells to anticancer drugs. In the current study we tested several other potential CaSR modulators, calcipotriol and the effective components of Chinese herbal medicine lentinan, for their functions in inducing CaSR expressi...

Palmoplantar psoriasis is classified into two types based on morphology- hyperkeratotic palmoplantar and pustular psoriasis. Hyperkeratotic presents with well defined erythematous scaly plaques overlying hyperkeratosis without the presence of sterile pustules, predominantly at palms and/or soles. There greater physical functional disability in patients Patients disease are more likely to suffer ...

1. Sklavounou A, Laskaris G. Oral psoriasis: report of a case and review of the literature. Dermatologica. 1990;180: 157--9. 2. Tosti A, Misciali C, Cameli N, Vincenzi C. Guess what! Psoriasis of the lips. Eur J Dermatol. 2001;11:589--90. 3. Rahman MA, Fikree M. Perioral psoriasis. J Eur Acad Dermatol Venereol. 2000;14:521--2. 4. Sehgal VN, Sehgal S, Verma P, Singh N, Rasool F. Exclusive plaque...

Nail involvement affects 80-90 % of patients with plaque psoriasis, and is even more prevalent in patients with psoriatic arthritis. This review is the result of a systemic approach to the literature and covers topical, intralesional, conventional systemic, and biologic systemic treatments, as well as non-pharmacological treatment options for nail psoriasis. The available evidence suggests that...

We have demonstrated that cytokine thymic stromal lymphopoietin (TSLP), whose expression is rapidly induced upon keratinocyte-selective ablation of retinoid X receptors (RXRs) -alpha and -beta in the mouse (RXRalphabeta(ep-/-) mice), plays a key role in initiating a skin and systemic atopic dermatitis-like phenotype. We show here that topical application of the physiologically active ligand [1a...

Vit i l igo i s an acquired depigmentat ion disorder of the skin in which there is loss of epidermal melanocytes. The prevalence of vitiligo is approximately 0.1-2% worldwide. The precise pathogenesis of vitiligo remains subtle and is probably multifactorial 1. Treatment of vitiligo remains an interesting topic and many centers have been reported as having varying degrees of success. Medical th...

Background: Seborrheic keratosis is a common benign tumor and many modalities are used to treat it. No convincing data favors the therapeutic effect of calcipotriol on seborrheic keratosis. We aimed to assess the efficacy of calcipotriol in the treatment of this tumor.Method: Eligible patients aged over 40 years with seborrheic keratosis (size: 5-15mm) were instructed to apply 50?g/g calcipotri...