significant effect on bioadhesive strength and in vitro drug release. It was found that carbopol gives higher bioadhesive strength than HPC. Comparatively HPC controls the drug release greater than carbopol. The optimized formulation follows non-Fickian release mechanism. The FT-IR and DTA studies indicate no physico-chemical interaction. Stability studies revealed that optimized formulation wa...

The aim of our study was to develop a liposomal carrier system for the local treatment of bacterial vaginosis, capable to efficiently deliver entrapped drug during an extended period of time. Chloramphenicol was entrapped in liposomes composed of egg phosphatidylcholine/egg phosphatidylgycerol-sodium (9:1, molar ratio) and prepared by two different methods, the proliposome method and the polyol...

INTRODUCTION Topicals are a mainstay in psoriasis vulgaris treatment and are used concomitantly even in patients receiving systemic therapy. Patient acceptance of topical treatment can impact adherence and, consequently, real-life effectiveness. This study aimed to identify patient preferences for topical treatment attributes and to evaluate patient acceptability of topical treatments. METHOD...

Herpes simplex keratitis (HSK) is a major cause of corneal blindness in the world. Following the primary infection, the virus enters into a latent phase. Recurrent infectious or immune keratitis cause structural damage to the cornea, scarring, and may lead to blindness. Several commercially available topical and oral antiviral drugs for HSK are currently available. However, toxicity and low pat...

The objects of this study were to develop the topical usage of ibuprofen gel and evaluate the permeability status of the prepared gel. Ibuprofen gel was prepared by incorporation of mustard oil and ethanol for improving the ibuprofen release in the topical preparation at different ratio low, medium and high concentration. In general marketed ibuprofen gel, ointment or creams contain ibuprofen a...

A degradable, cytocompatible bioadhesive can facilitate surgical procedures and minimize patient pain and post-surgical complications. In this study a bioadhesive hydrogel system based on oxidized methacrylated alginate/8-arm poly(ethylene glycol) amine (OMA/PEG) has been developed, and the bioadhesive characteristics of the crosslinked OMA/PEG hydrogels evaluated. Here we demonstrate that the ...

Biofreeze, a topical analgesic, is commonly used as a coupling medium during therapeutic ultrasound to add greater relief of pain, although it may block transmission of ultrasound energy. Our objective was to compare a mixture of 1-part Biofreeze and 3-parts ultrasound gel to 100% ultrasound gel to assess intramuscular heating and perceived sensation of heat. Fifteen participants received a con...

Liposomal formulations were significantly explored over the last decade for the ophthalmic drug delivery applications. These formulations are mainly composed of phosphatidylcholine (PC) and other constituents such as cholesterol and lipid-conjugated hydrophilic polymers. Liposomes are biodegradable and biocompatible in nature. Current approaches for topical delivery of liposomes are focused on ...

Some topical fluorides cause surface changes in dental materials. The purpose of this study was to compare the effects of a topical acidulated phosphate sodium fluoride (1.23% APF) foam with the effects of other topical fluorides on the surface of veneer porcelain. Forty porcelain specimens (Ceramco) were placed into eight groups (N = 5). Four groups were immersed in either 1.23% APF foam, 1.23...

This paper describes hitherto developed drug forms for topical ocular administration, that is, eye drops, ointments, in situ gels, inserts, multicompartment drug delivery systems, and ophthalmic drug forms with bioadhesive properties. Heretofore, many studies have demonstrated that new and more complex ophthalmic drug forms exhibit advantage over traditional ones and are able to increase the bi...