OBJECTIVE To determine the time course of changes in glucagon and insulin secretion in children with recently diagnosed type 1 diabetes. RESEARCH DESIGN AND METHODS Glucagon and C-peptide concentrations were determined in response to standard mixed meals in 23 patients with type 1 diabetes aged 9.4 +/- 4.6 years, beginning within 6 weeks of diagnosis, and every 3 months thereafter for 1 year....

A growing frustration in clinical medicine is that we are now so busy managing the proliferation of risk factors, “incidentalomas,” and the worried well that we lack the time to care properly for those who are seriously ill. As the definitions of common conditions such as diabetes and kidney disease have expanded and the categories and boundaries of mental disorders have grown, our time and att...

Several studies have shown that most climate models underestimate cloud cover and overestimate reflectivity, particularly for the tropical low-level clouds. Here, we analyze characteristics of marine clouds simulated by six models, which provided COSP output within CMIP6 project. CALIPSO lidar observations PARASOL mono-directional reflectance are used model evaluation. It is found “too few, too...

Most significant policy issues facing humanity reach across national borders. Consequential political decisions with cross-national effects are frequently made by states, non-state organisations, and corporations. Under these circumstances, it is widely acknowledged that important to conduct deliberation at the global level. Below this shallow agreement, however, lies deep disagreement about a ...