نتایج جستجو برای: tmprss2
تعداد نتایج: 875 فیلتر نتایج به سال:
Infection by enveloped coronaviruses (CoVs) initiates with viral spike (S) proteins binding to cellular receptors, and is followed by proteolytic cleavage of receptor-bound S proteins, which prompts S protein-mediated virus-cell membrane fusion. Infection therefore requires close proximity of receptors and proteases. We considered whether tetraspanins, scaffolding proteins known to facilitate C...
INTRODUCTION AND OBJECTIVE ERG oncogene fusions (predominantly TMPRSS2-ERG) represent the most common (50-70% frequency) and validated prostate cancer (CaP) genome alteration in the Western countries. A common TMPRSS2-ERG fusion type leads to the androgen dependent tumor cell specific expression of the TMPRSS2-ERG fusion transcript and amino terminally truncated ERG oncoprotein. CaP prevalence ...
Acute kidney injury (AKI) is a common complication, affecting up to 37% of hospitalized patients with SARS-CoV-2 infection and proportional its severity portends poor prognosis. Diverse mechanisms have been proposed studies reported conflicting results. Moreover, renal tropism does not equate pathogenicity. For virus be pathogenic, in addition affinity (tropism) for specific tissue(s), host cel...
Summary SARS-CoV-2 infection is associated with lower blood oxygen levels, even in patients without hypoxia requiring hospitalization. This discordance illustrates the need for a more unifying explanation as to whether directly or indirectly affects erythropoiesis. Here, we show significantly enriched CD71+ erythroid precursors/progenitors circulation of COVID-19 patients. W...
BACKGROUND Whether the genomic rearrangement transmembrane protease, serine 2 (TMPRSS2):v-ets erythroblastosis virus E26 oncogene homolog (ERG) has prognostic value in prostate cancer is unclear. METHODS Among men with prostate cancer in the prospective Physicians' Health and Health Professionals Follow-Up Studies, we identified rearrangement status by immunohistochemical assessment of ERG pr...
TMPRSS2/ERG rearrangement, PTEN gene deletion, and androgen receptor (AR) gene amplification have been observed in various stages of human prostate cancer. We hypothesized that using these markers as a combined panel would allow better differentiation between low-risk and high-risk prostate cancer. We analyzed 110 primary prostate cancer samples, 70 metastatic tumor samples from 11 patients, an...
Introduction: Although males and females have the same prevalence of COVID-19, a variation in severity symptoms between has been observed. We hypothesize that this can partly be explained by effect androgens on infectious activity SARS-Cov2 virus.
 Aims: This study investigated sex two androgenic drugs testosterone oxandrolone mRNA expression several entry genes: angiotensin-converting enz...
Abstract Objectives Recent advances in defining the genetic landscape of has shown host cell- SARS-CoV-2 interaction via ACE2 protein and presence at least three additional virus invasion genes including TMPRSS2, FURIN, CD147/BSG. In current study, we investigated mutation m-RNA expression patterns target by evaluating associations between epigenetic mechanisms susceptibility infection renal ca...
Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) infecting mechanism depends on hosting angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) as essential components and androgens as regulators for inducing the expression of these components. Therefore, hyperandrogenism-related disease such as polycystic ovary syndrome (PCOS) in insulin resistant wome...
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