Milk is a source of bioactive proteins with defensive properties great value for protecting the newborn. The activity bovine milk lactoferrin (LF) was investigated as an antibacterial agent in internalisation emergent pathogen Cronobacter sakazakii into Caco-2/TC7 cells, model human intestinal epithelium. effect LF on oxidative stress and expression Toll-like receptors (TLR) also investigated. ...

Abstract Background Pulmonary fibrosis (PF) is a progressive and lethal lung disease of elderly whose incidence has been increasing following the Covid-19 pandemic caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). PF immunopathogenesis involves alveolar epithelial cell damage, release damage-associated molecular patterns (DAMPs), extracellular matrix (ECM) injury. We asse...

Patients with diffuse large cell lymphoma who have an adequate vitamin D supply derive significantly more benefit from immuno-chemotherapy rituximab than patients deficiency; this is especially true for female patients. We already been able to show that increases the antibody-dependent cytotoxicity (ADCC) of NK cells in a sex-dependent manner, but it unclear how makes efficient. Methods: Health...

Abstract Itaconate is a unique regulatory metabolite that induced upon toll-like receptor (TLR) stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death phenotypes associated with itaconate production activated macrophages. We show endogenous key regulator of the signal 2 NLRP3 inflammasome activation after long LPS priming which establishes to late activat...

Histological chorioamnionitis (HCA) is an established marker of ascending infection, a major cause of preterm birth. No studies have characterised the global change in expression of genes involved in the toll-like receptor (TLR) signalling pathways in the presence of HCA in the setting of preterm birth (pHCA). Fetal membranes were collected immediately after delivery and underwent histological ...

Our previous study has shown berberine prevents damage to the intestinal mucosal barrier during early phase of sepsis in rat through mechanisms independent of the NOD-like receptors signaling pathway. In this study, we explored the regulatory effects of berberine on Toll-like receptors during the intestinal mucosal damaging process in rats. Male Sprague-Dawlay (SD) rats were treated with berber...

The ability to respond properly to Toll-like receptor (TLR) ligands may be impaired by polymorphisms within the TLR family of genes, which results in an altered susceptibility to cancers. However, the results of epidemiological studies remained inconsistent. To assess the effect of four selected polymorphisms (rs5743708, -196 to -174 del polymorphism, rs3804099, and rs3804100) in TLR-2 on cance...