نتایج جستجو برای: tlr

تعداد نتایج: 8542  

Journal: :Journal of Immunology 2023

Abstract Macrophages play a variety of roles in immunity including both pro- and anti-inflammatory functions, which can be controlled by toll-like receptor (TLR) stimulation. Previously, we generated computational model interconnected TLR signaling cascades validated the using experimental data from THP-1 monocyte cell line. This project aimed to adapt provide insights into activation bone marr...

Journal: :journal of cellular and molecular anesthesia 0
parissa sezari assistant professor, anesthesiology research center, shahid beheshti university of medical sciences, tehran, iran; tel/fax: +98 21 2243 2572

the toll like (family of receptors tlr) are expressed primarily by immune cells and are known to be part of innate immune system. in the past decade involvement of tlrs in several physiologic and pathologic pathways has been proved. pain transmission via glial activation is one of such interesting fields. both pathological pain states and treatment have also been shown to be related to tlr-rela...

2016
Maryam Rameshrad Nasrin Maleki-Dizaji Hamid Soraya Negisa Seyed Toutounchi Abolfazl Barzegari Alireza Garjani

OBJECTIVES TLR-4 activates a number of inflammatory signaling pathways. Also, AMPK could be involved in anti-inflammatory signaling. The aim of this study was to identify whether stimulation of AMPK could inhibit LPS-induced Tlr-4 gene expression in mice hearts. MATERIALS AND METHODS Heart AMPK activity and/or Tlr-4 expression was stimulated in different mice groups, using respectively IP inj...

2013
Antoine Roquilly Cécile Braudeau Raphael Cinotti Erwan Dumonte Rémi Motreul Régis Josien Karim Asehnoune

PREVIOUS PRESENTATION Portions of this study were presented at the Annual Congress of Société Française d'Anesthésie et de Réanimation in Paris, September 2012. BACKGROUND Toll-like receptor (TLR) agonists are promising therapy for the prevention of nosocomial infections in critical ill patients. We aimed to analyze the TLR-reactivity of circulating dendritic cells (DC) as assessed by cytokin...

2016
Shiqiao Peng Chenyan Li Xinyi Wang Xin Liu Cheng Han Ting Jin Shanshan Liu Xiaowen Zhang Hanyi Zhang Xue He Xiaochen Xie Xiaohui Yu Chuyuan Wang Ling Shan Chenling Fan Zhongyan Shan Weiping Teng

OBJECTIVE Autoimmune thyroid disease (AITD) is an organ-specific disorder due to the interplay between environmental and genetic factors. Toll-like receptors (TLRs) are pattern recognition receptors expressed abundantly on monocytes. There is a paucity of data on TLR expression in AITD. The aim of this study was to examine TLR expression, activation, ligands, and downstream signaling adaptors i...

2017
Chenyang Liu Min Wang Wenkui Sun Feng Cai Shen Geng Xin Su Yi Shi

Aspergillus fumigatus (A. fumigatus) is one of the most common fungal pathogens of invasive pulmonary aspergillosis (IPA), which may be life threatening in immunocompromised individuals. The dendritic cell-associated C-type lectin receptor (Dectin-1), toll‑like receptor (TLR)-2 and TLR-4 are major pattern recognition receptors in alveolar macrophages that recognize A. fumigatus components. The ...

Journal: :Annals of the New York Academy of Sciences 2013
Cheng Qian Xuetao Cao

Toll-like receptors (TLRs) are critical pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs), which are conserved and specific molecular "signatures" expressed by pathogens. TLR ligation triggers distinct but shared signaling pathways that lead to effector mechanisms in innate immune responses. TLR specificity and activation are strictly and finely ...

Journal: :Cell 2007
Carla V. Rothlin Sourav Ghosh Elina I. Zuniga Michael B.A. Oldstone Greg Lemke

The activation of Toll-like receptors (TLRs) in dendritic cells (DCs) triggers a rapid inflammatory response to pathogens. However, this response must be tightly regulated because unrestrained TLR signaling generates a chronic inflammatory milieu that often leads to autoimmunity. We have found that the TAM receptor tyrosine kinases-Tyro3, Axl, and Mer-broadly inhibit both TLR and TLR-induced cy...

2014
M Madeshwaran V Gupta J Chakrabarty G Narayan A Kumar

Results Mean age of study population was 8.08 ± 3.41 years. 75% of patients were in WHO clinical stage I and II, whereas 25% in stage III. 29% HIV children had severe immunosuppression. TLR-1 showed neutral expression in majority (96%) of HIV children. For TLR-7, 53.5% HIV children showed upregulation, whereas 32% and 14.5% showed downregulation and neutral expression, respectively. TLR-8 expre...

Journal: :Cancer research 2012
Maria Shatz Daniel Menendez Michael A Resnick

The transcription factor p53 regulates genes associated with a wide range of functions, including the Toll-like receptor (TLR) set of innate immunity genes, suggesting that p53 also modulates the human immune response. The TLR family comprises membrane glycoproteins that recognize pathogen-associated molecular patterns (PAMP) and mediate innate immune responses, and TLR agonists are being used ...

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