This paper focuses on the role of frequency spectral tilt (TL) of the voicing source waveform, the glottal turbulent noise and fluctuations of the source spectrum on period-to-period basis in the cognition of paralinguistic features as in suspicious and disappointed renditions. The TL is closely related to duration of the return phase of the differentiated glottal waveform. Perceptual experimen...

Volcanic ash contains thallium (Tl), which is highly toxic to the biosphere. The aim of this study was to determine the Tl concentration in fractions of volcanic ash samples originating from the Eyjafjallajökull volcano. A sequential extraction scheme allowed for a study of element migration in the environment. Differential pulse anodic stripping voltammetry using a flow measuring system was se...

Two components of the RNA polymerase (RNAP) catalytic center, the bridge helix and the trigger loop (TL), have been linked with changes in elongation rate and pausing. Here, single molecule experiments with the WT and two TL-tip mutants of the Escherichia coli enzyme reveal that tip mutations modulate RNAP's pause-free velocity, identifying TL conformational changes as one of two rate-determini...

In the thermoluminescence (TL) glow curve of photosystem II, particles depleted of manganese, a tyrosine modifier, 7-chloro-4-nitrobenz-2-oxa-1,3-diazole (NBD) abolishes the TL band appearing around -55 degrees C (TL-55). Addition of a histidine modifier, diethylpyrocarbonate results in the disappearance of the band peaking around -30 degrees C (TL-30). NBD treatment also abolishes the EPR sign...

Proteasome degrades proteins in eukaryotic cells. As such, the proteasome is crucial in cell cycle and function. This study proved that microcystin-LR (MC-LR), which is a toxic by-product of algal bloom, can target cellular proteasome and selectively inhibit proteasome trypsin-like (TL) activity. MC-LR at 1 nM can inhibit up to 54% of the purified 20S proteasome TL activity and 43% of the prote...

Disadvantaged social environments are associated with adverse health outcomes. This has been attributed, in part, to chronic stress. Telomere length (TL) has been used as a biomarker of chronic stress: TL is shorter in adults in a variety of contexts, including disadvantaged social standing and depression. We use data from 40, 9-y-old boys participating in the Fragile Families and Child Wellbei...

The midgut of the American silkworm transports potassium actively from blood side to lumen. The active K transport was measured by short-circuiting the gut. The K transport is inhibited by Tl in the lumen solution. A Lineweaver-burk plot showed that the inhibition with Tl is competitive with the active K transport. The Km was found to be 5.7 +/- 0.7 and Ki = 0.1. It was conclude that Tl acts on...

PIN77 A Cost-EffECtIvENEss EvAluAtIoN for A NEw thErAPy IN hIv trEAtmENt Malhan S.1, Kockaya G.2, Elbir Zengin T.2, Dalgic C.2, Yenilmez F.B.3, Cerci P.3, Oksuz E.1, Tayfun K.2, Unal S.3 1Baskent University, Ankara, Turkey, 2Gilead Science, Istanbul, Turkey, 3Hacettepe University, Ankara, Turkey Objectives: Economical evaluation of Stribild in Turkey, which is a single tablet regimen indicated ...

INTRODUCTION Cushing's syndrome (CS) increases cardiovascular risk (CVR) and adipocytokine imbalance, associated with an increased inflammatory state. Telomere length (TL) shortening is a novel CVR marker, associated with inflammation biomarkers. We hypothesized that inflammatory state and higher CVR in CS might be related to TL shortening, as observed in premature aging. AIM To evaluate rela...

Age-associated telomere shortening is a well documented feature of peripheral blood cells in human population studies, but it is not known to what extent these data can be transferred to the individual level. Telomere length (TL) in two blood samples taken at approximately 10 years interval from 959 individuals was investigated using real-time PCR. TL was also measured in 13 families from a mul...